Dystonia in Childhood: How Insights from Paediatric Research Enrich the Network Theory of Dystonia.
Dystonia in Childhood: How Insights from Paediatric Research Enrich the Network Theory of Dystonia.
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童年的肌张力障碍：儿科研究的见解如何丰富肌张力障碍的网络理论。
DOI：
10.1007/978-3-031-26220-3_1
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发表时间：
2023
影响因子：
--
通讯作者：
McClelland VM
中科院分区：
文献类型：
--
作者：
McClelland VM
肌张力障碍现在被广泛认为是一种网络障碍，多个脑区及其相互连接在病理生理学中发挥着潜在的作用。该模型调和了以前被视为关于该疾病的神经解剖学和神经生理学特征的相互矛盾的发现，但在对潜在病理生理学的科学理解方面仍然存在重大差距。最大的未解决的挑战之一是了解发育中大脑的肌张力障碍网络模型。本文概述了儿童肌张力障碍的研究如何支持和促进网络理论，并强调了儿科研究数据揭示了新颖独特的生理学见解的方面，对理解整个生命周期的肌张力障碍具有重要意义。
Dystonia is now widely accepted as a network disorder, with multiple brain regions and their interconnections playing a potential role in the pathophysiology. This model reconciles what could previously have been viewed as conflicting findings regarding the neuroanatomical and neurophysiological characteristics of the disorder, but there are still significant gaps in scientific understanding of the underlying pathophysiology. One of the greatest unmet challenges is to understand the network model of dystonia in the context of the developing brain. This article outlines how research in childhood dystonia supports and contributes to the network theory and highlights aspects where data from paediatric studies has revealed novel and unique physiological insights, with important implications for understanding dystonia across the lifespan.