Inactivation and metabolism of neuropeptides.
Inactivation and metabolism of neuropeptides.
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神经肽的失活和代谢。
DOI：
10.1146/annurev.ne.09.030186.002215
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发表时间：
1986
影响因子：
13.9
通讯作者：
S. Blumberg
中科院分区：
文献类型：
--
作者：
J. McKelvy;S. Blumberg
在过去的十年中，神经肽，定义为已知结构的肽分泌的神经元，已受到越来越多的关注，作为可能的细胞间信号在无脊椎动物和脊椎动物的神经系统。(For最近的综合论文，见Krieger et al 1983。尽管神经肽的作用机制仍不清楚，但足够的实验证据表明，至少某些神经肽对神经靶细胞具有重要的生理作用[例如两栖动物交感神经节神经元上的LHRH样肽（1983年1月和1月）; P物质对豚鼠肠系膜下神经节细胞的作用（Dun & Minota 1981）]，以保证考虑如何终止这些作用。细胞间信号的失活必须被看作是一个复杂的过程，从受体被这些分子激活到它们从携带它们的受体的区域“清除”。根据这一论点，扩散远离受体、集中再摄取、细胞内外酶水解或共价修饰、以及与受体相关的内化或其组合的过程是可能的。
Over the past decade, neuropeptides, defined as peptides of known structure secreted by neurons, have received increasing attention as possible intercellular signals in both invertebrate and vertebrate nervous systems. (For a recent comprehensive treatise, see Krieger et al 1983.) Although the mechanisms of neuropeptide action are still mostly unknown, sufficient experimental evidence suggests that at least some neuropeptides have physiologically important actions on neural target cells [e.g. an LHRH-like peptide on amphibian sympathetic ganglionic neurons (Jan & Jan 1983); substance P on guinea pig inferior mesenteric ganglion cells (Dun & Minota 1981)] to warrant consideration of how these actions might be terminated. The inactivation of intercellular signals must be viewed as a complex process extending from the point of receptor activation by these molecules to their "clearance" from the area bearing their receptors. By this argument, the processes of diffusion away from the receptor, concentrative reuptake, extra and intracellular enzymatic hydrolysis or covalent modifi cation, and internalization in association with receptor, or combinations of
青蛙交感神经节中胆碱能和肽能递质的共存和共同释放。
DOI：
--
发表时间：
1983
期刊：
Federation proceedings
影响因子：
--
作者：
Jan,YN;Jan,LY
通讯作者：
Jan,LY