INDOOR AIR-POLLUTION EXPOSURE AND LOWER RESPIRATORY-INFECTIONS IN YOUNG GAMBIAN CHILDREN
INDOOR AIR-POLLUTION EXPOSURE AND LOWER RESPIRATORY-INFECTIONS IN YOUNG GAMBIAN CHILDREN
复制标题
DOI：
10.1093/ije/20.2.424
复制
发表时间：
1991-06-01
影响因子：
7.7
通讯作者：
CAMPBELL, H
中科院分区：
文献类型：
--
作者：
ARMSTRONG, JRM;CAMPBELL, H
在一项以农村人口为基础的队列研究中，对大约500名5岁以下的冈比亚儿童进行了为期一年的随访，急性下呼吸道感染（ALRI）的发病率与各种风险因素有关，包括父母吸烟和做饭时经常背着母亲，这是暴露于烹饪火灾烟雾的替代措施。 采用“儿童周风险”方法进行了两项统计分析，包括和排除同一儿童的多次疾病发作。 每周对ALRI的监测发现62名儿童发生了75起事件。 使用这两种方法进行的分层分析表明，父亲吸烟，以及仅对女孩而言，做饭时母亲背上的背和一夫多妻制家庭的一部分是与感染相关的主要风险因素：当排除同一儿童多次发作时，没有健康卡是一岁以上儿童的额外风险因素。 对这两种方法的数据（包括每一个风险因素以及性别、年龄、村庄和季节）进行的多元逻辑回归建模表明，父亲吸烟、做饭时母亲背在背上以及成为一夫多妻制家庭的一部分会增加ALRI的风险，后两种风险仅适用于女孩。 排除同一儿童多次发作的分析还表明，没有健康卡是1-5岁儿童的风险因素。 解释这些发现的困难进行了讨论。
In a rural population-based cohort study of approximately 500 Gambian children under five years old followed for one year, incidence of acute lower respiratory infections (ALRI) was related to various risk factors including parental smoking and regular carriage on the mother's back while cooking, a proxy measure for exposure to smoke from cooking fires. Two statistical analyses using a 'child-weeks at risk' approach were carried out, including and excluding multiple disease episodes in the same child. Weekly surveillance for ALRI found 75 episodes in 62 children. Stratified analyses using both approaches suggested father's smoking, and, for girls only, carriage on the mother's back while cooking and being part of a polygamous family were the main risk factors associated with infection: when multiple episodes occurring in the same child were excluded, not having a health card was an additional risk factor in children over a year old. Multiple logistic regression modelling of data from both approaches, including each of these risk factors and sex, age, village and season, suggested father's smoking, carriage on the mother's back while cooking and being part of a polygamous family increase risk of ALRI, the latter two for girls only. The analysis excluding multiple episodes in the same child also suggested that not having a health card is a risk factor for children aged 1-5 years. The difficulties in interpreting these findings are discussed.