Recruitment of inhibition and excitation across mouse visual cortex depends on the hierarchy of interconnecting areas
Recruitment of inhibition and excitation across mouse visual cortex depends on the hierarchy of interconnecting areas
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DOI：
10.7554/elife.19332
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发表时间：
2016-09-26
期刊：
影响因子：
7.7
通讯作者：
Burkhalter, Andreas
中科院分区：
文献类型：
--
作者：
D'Souza, Rinaldo David;Meier, Andrew Max;Burkhalter, Andreas
感觉刺激的不同特征在不同的大脑区域被选择性地处理。抑制神经元和兴奋神经元在一个区域内的相对募集控制着适当刺激编码的神经元增益。我们通过绘制前馈和反馈通路中锥体和小蛋白（PV）表达神经元的突触输入的位置和强度，研究了这种抑制和兴奋的平衡是如何在皮层层次的多个水平上不同地招募的。前馈和反馈通路连接初级（V1）和两个高级视觉区域。虽然PV神经元在所有2/3层通路的区间兴奋强于锥体神经元，但我们观察到从最前馈通路到最反馈通路的抑制/兴奋比逐渐缩小。我们的研究结果表明，区域间增益控制取决于源和目标的层次位置、信息流在网络中的方向以及目标神经元的层流位置。
Diverse features of sensory stimuli are selectively processed in distinct brain areas. The relative recruitment of inhibitory and excitatory neurons within an area controls the gain of neurons for appropriate stimulus coding. We examined how such a balance of inhibition and excitation is differentially recruited across multiple levels of a cortical hierarchy by mapping the locations and strengths of synaptic inputs to pyramidal and parvalbumin (PV)-expressing neurons in feedforward and feedback pathways interconnecting primary (V1) and two higher visual areas. While interareal excitation was stronger in PV than in pyramidal neurons in all layer 2/3 pathways, we observed a gradual scaling down of the inhibition/excitation ratio from the most feedforward to the most feedback pathway. Our results indicate that interareal gain control depends on the hierarchical position of the source and the target, the direction of information flow through the network, and the laminar location of target neurons.