Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis
Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis
复制标题
DOI：
10.1002/art.21601
复制
发表时间：
2005-12-15
期刊：
影响因子：
--
通讯作者：
Felson, DT
中科院分区：
文献类型：
--
作者：
Bischoff-Ferrari, HA;Zhang, YQ;Felson, DT
Objective.探讨原发性膝骨关节炎（OA）患者血清25-羟基维生素D（25[OH]D）水平与骨密度（BMD）的关系。我们进行了一项基于人口的调查，Frawling研究。共确定了228例初次影像学膝关节CIA受试者。对于维生素D状态，25（OH）D水平32 ng/ml被归类为维生素D充足。我们使用线性回归模型比较CIA受试者25（OH）D水平类别之间的平均BMD，同时调整性别、年龄、体重指数（BMI）、膝关节疼痛、体力活动、队列和疾病严重程度。平均年龄为74.4岁，36%为男性。在228人中，15%的人缺乏维生素D，51%的人维生素D缺乏，34%的人维生素D充足。与维生素D缺乏的受试者相比，维生素D缺乏的受试者BMD高7.3%（校正百分比差异; P = 0.02），维生素D充足的受试者BMD高8.5%（校正百分比差异; P = 0.02;跨类别趋势检验：P = 0.04）。我们观察到原发性膝关节CIA患者血清25（OH）D和BMD之间存在显著正相关，与性别、年龄、BMI、膝关节疼痛、体力活动和疾病严重程度无关。鉴于膝关节OA患者中低25（OH）D状态的高患病率以及25（OH）D与BMD之间的正相关性，补充维生素D可能会增强OA患者的BMD。
Objective. To describe the association between serum 25-hydroxyvitamin D (25[OH]D) level and bone mineral density (BMD) in persons with primary knee osteoarthritis (OA).Methods. We conducted a population-based survey of the Framingham Study. A total of 228 subjects with primary radiographic knee CIA were identified. For vitamin D status, 25(OH)D levels 32 ng/ml were classified as vitamin D replete. We compared average BMD between categories of 25(OH)D levels in subjects with CIA using a linear regression model while adjusting for sex, age, body mass index (BMI), knee pain, physical activity, cohort, and disease severity.Results. Mean age was 74.4 years and 36% were men. Of 228 individuals, 15% were vitamin D deficient, 51% had hypovitaminosis D, and 34% were vitamin D replete. Compared with subjects with vitamin D deficiency, those with hypovitaminosis D had a 7.3% higher BMD (adjusted percent difference; P = 0.02) and vitamin D replete subjects had an 8.5% higher BMD (adjusted percent difference; P = 0.02; test for trend across categories: P = 0.04).Conclusion. We observed a significant positive association between serum 25(OH)D and BMD in individuals with primary knee CIA, independent of sex, age, BMI, knee pain, physical activity, and disease severity. Given the high prevalence of low 25(OH)D status in persons with knee OA and the positive association between 25(OH)D and BMD, vitamin D supplementation may enhance BMD in individuals with OA.