GDNF - A GLIAL-CELL LINE DERIVED NEUROTROPHIC FACTOR FOR MIDBRAIN DOPAMINERGIC-NEURONS
GDNF - A GLIAL-CELL LINE DERIVED NEUROTROPHIC FACTOR FOR MIDBRAIN DOPAMINERGIC-NEURONS
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DOI：
10.1126/science.8493557
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发表时间：
1993-05-21
期刊：
影响因子：
56.9
通讯作者：
COLLINS, F
中科院分区：
文献类型：
--
作者：
LIN, LFH;DOHERTY, DH;COLLINS, F
纯化并克隆了一种增强中脑多巴胺能神经元存活的强效神经营养因子。胶质细胞源性神经营养因子（GDNF）是一种糖基化的二硫键同源二聚体，是转化生长因子β超家族的远亲成员。在胚胎中脑培养中，重组人GDNF促进多巴胺能神经元的存活和形态分化，并增加其高亲和力多巴胺摄取。这些影响是相对具体的，GDNF没有增加总神经元或星形胶质细胞的数量，也没有增加γ-氨基丁酸和多巴胺能神经元的递质摄取。GDNF可用于治疗以中脑多巴胺能神经元进行性变性为特征的帕金森病。
A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake. These effects were relatively specific; GDNF did not increase total neuron or astrocyte numbers nor did it increase transmitter uptake by gamma-aminobutyric-containing and serotonergic neurons. GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.