New prolyl 4‐hydroxylase inhibitor reduces procollagen gene expression and enzyme‐altered lesions in rat liver cirrhosis
New prolyl 4‐hydroxylase inhibitor reduces procollagen gene expression and enzyme‐altered lesions in rat liver cirrhosis
复制标题
新型脯氨酰 4-羟化酶抑制剂可降低大鼠肝硬化中前胶原基因表达和酶改变病变
DOI：
--
复制
发表时间：
1995
影响因子：
4.1
通讯作者：
K. Okita
中科院分区：
文献类型：
--
作者：
I. Sakaida;K. Okita
缺乏胆碱的l-氨基酸限定（CDAA）饮食导致雄性Wistar大鼠在16周后发生肝硬化。新型脯氨酰4-羟化酶抑制剂2，4-吡啶二羧酸双[（2-甲氧基乙基酰胺）]（HOE 077）以剂量依赖性方式预防肝纤维化，血清丙氨酸转氨酶和天冬氨酸转氨酶升高未降低，同时抗谷胱甘肽S-转移酶胎盘型抗体染色的肿瘤前酶改变病变减少。HOE 077以剂量依赖性方式降低了血清III型前胶原肽（PIIIP）的增加，并与喂食CDAA饲料的大鼠肝脏中III型前胶原mRNA表达的降低成比例。
A choline deficient l‐amino acid defined (CDAA) diet led to the development of liver cirrhosis in male Wistar rats after 16 weeks. A new prolyl 4‐hydroxylase inhibitor, 2,4‐pyridine dicarboxylic acid bis [(2‐methoxyethyl amide)] (HOE 077), prevented liver fibrosis in a dose‐dependent manner without a reduction in increased serum alanine aminotransferase and aspartate aminotransferase in parallel with a reduction in preneoplastic enzyme‐altered lesions stained with anti‐glutathione S‐transferase placental form antibody. HOE 077 reduced the increase in serum procollagen III peptide (PIIIP) in a dose‐dependent manner and in proportion to the reduction in mRNA expression of type III procollagen in the liver of rats fed a CDAA diet.
缺乏胆碱的饮食诱导的肝微粒体膜的脂质过氧化及其与饮食诱导的γ-谷氨酰转肽酶阳性灶的诱导的关系。
影响因子：
11.2
作者：
Perera,MI;Demetris,AJ;Katyal,SL;Shinozuka,H
通讯作者：
Shinozuka,H