Oxidative Stress and Antioxidant Parameters in Patients With Major Depressive Disorder Compared to Healthy Controls Before and After Antidepressant Treatment: Results From a Meta-Analysis
Oxidative Stress and Antioxidant Parameters in Patients With Major Depressive Disorder Compared to Healthy Controls Before and After Antidepressant Treatment: Results From a Meta-Analysis
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DOI：
10.4088/jcp.14r09179
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发表时间：
2015-12-01
影响因子：
5.3
通讯作者：
Correll, Christoph U.
中科院分区：
文献类型：
--
作者：
Jimenez-Fernandez, Sara;Gurpegui, Manuel;Correll, Christoph U.
目的：研究氧化应激和抗氧化剂在抑郁症中的作用。数据来源：我们通过MEDLINE/PubMed、科克伦图书馆、菲斯特拉和Galenicom从数据库建立到2013年12月31日检索了文献，没有语言限制，并辅以相关文章的手工检索。检索词包括（1）氧化应激、抗氧化剂 *、亚硝化应激、硝化应激、硝基氧化应激、自由基 * 和个体氧化应激标志物/抗氧化剂的名称和（2）抑郁症及相关疾病和抗抑郁药。包括在抑郁症患者中比较抗氧化剂或氧化应激标志物与抗抑郁治疗前后的健康对照的研究。数据提取：两位作者独立提取了抗氧化剂或氧化应激标志物的数据。计算来自>= 3项研究的结果的标准化平均差异（SMD）+/- 95%置信区间（CI）。（N = 3 961;抑郁症患者= 2，477，健康对照= 1，484）报告了氧化应激标志物丙二醛（MDA）和总亚硝酸盐，抗氧化剂尿酸和锌，或抗氧化增强酶超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPX）。当抑郁症患者与健康对照组相比时，抑郁症与较高的氧化应激MDA水平相关（8项研究; n = 916; SMD = 1.34; 95%CI，0.57至2.11; P
Objective: To investigate the role of oxidative stress and antioxidants in depression.Data Sources: We searched the literature without language restrictions through MEDLINE/PubMed, Cochrane Library, Fisterra, and Galenicom from database inception until December 31, 2013, supplemented by a hand search of relevant articles. Search terms included (1) oxidative stress, antioxidant*, nitrosative stress, nitrative stress, nitro-oxidative stress, free radical*, and names of individual oxidative stress markers/antioxidants and (2) depression and related disorders and antidepressant.Study Selection: Included were studies in patients with depression comparing antioxidant or oxidative stress markers with those in healthy controls before and after antidepressant treatment.Data Extraction: Two authors independently extracted the data for antioxidant or oxidative stress markers. Standardized mean differences (SMDs) +/- 95% confidence intervals (CIs) for results from >= 3 studies were calculated.Data Synthesis: Altogether, 29 studies (N = 3,961; patients with depression = 2,477, healthy controls = 1,484) reported on the oxidative stress marker malondialdehyde (MDA) and total nitrites, the antioxidants uric acid and zinc, or the antioxidant-enhancing enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX). When patients with depression were compared with healthy controls, depression was associated with higher oxidative stress MDA levels (8 studies; n = 916; SMD = 1.34; 95% CI, 0.57 to 2.11; P