Overeating Behavior and Striatal Dopamine with 6-[F]-Fluoro-L-m-Tyrosine PET.
Overeating Behavior and Striatal Dopamine with 6-[F]-Fluoro-L-m-Tyrosine PET.
复制标题
暴饮暴食行为和纹状体多巴胺与 6-[F]-氟-L-m-酪氨酸 PET。
DOI：
10.1155/2010/909348
复制
发表时间：
2010
影响因子：
3.3
通讯作者：
Jagust,WilliamJ
中科院分区：
文献类型：
--
作者：
Wilcox,ClaireE;Braskie,MeredithN;Kluth,JenniferT;Jagust,WilliamJ
Eating behavior may be affected by dopamine synthesis capacity. In this study, 6‐[18F]‐fluoro‐L‐m‐tyrosine (FMT) positron emission tomography (PET) uptake in striatal subregions was correlated with BMI (kg/m2) and an estimate of the frequency of prior weight loss attempts in 15 healthy subjects. BMI was negatively correlated with FMT uptake in the dorsal caudate. Although the association between BMI and FMT uptake in the dorsal caudate was not significant upon correction for age and sex, the association fell within the range of a statistical trend. Weight loss attempts divided by years trying was also negatively correlated with FMT uptake in the dorsal putamen (P= .05). These results suggest an association between low dorsal striatal presynaptic dopamine synthesis capacity and overeating behavior.
