Perivascular dendritic macrophages as immunobiological constituents of the human dermal microvascular unit.
Perivascular dendritic macrophages as immunobiological constituents of the human dermal microvascular unit.
复制标题
血管周围树突状巨噬细胞作为人真皮微血管单元的免疫生物学成分。
DOI：
10.1111/1523-1747.ep12581078
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Sontheimer,RD
中科院分区：
文献类型：
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作者：
Sontheimer,RD
我们最近观察到了一个以前未表征的 II 类 (Ia) 抗原阳性树突状细胞群，它们与正常成人和新生儿皮肤的真皮微血管密切相关。免疫荧光和免疫电子显微镜研究表明该细胞是血管周围巨噬细胞。这种真皮血管周围树突状巨噬细胞在浅表血管丛中密度最大，似乎占真皮巨噬细胞总数的很大一部分。由于组织巨噬细胞并不总是与循环单核细胞/巨噬细胞具有相同的免疫库，因此我们对检查这种真皮树突巨噬细胞的功能性免疫能力产生了兴趣。开发了一种程序来从正常人新生儿包皮中分离和部分纯化这些细胞。初步研究结果与这些细胞具有向 CD4+T 细胞呈递同种异体抗原的能力的可能性相一致。这种真皮血管周围巨噬细胞的潜在免疫功能在其与真皮微血管单元的其他细胞成分（即微血管内皮细胞、血管周围 T 细胞和肥大细胞）可能相互作用的背景下进行讨论。J Invest Dermatol 93:96S–101S, 1989
We have recently observed a previously uncharacterized population of class II (Ia) antigen-positive dendritic cells that is intimately associated with the dermal microvessels of normal human adult and newborn skin. Immunofluorescence and immunoelectron microscopy studies have indicated that this cell is a perivascular macrophage. This dermal perivascular dendritic macrophage was seen in greatest density in the superficial vascular plexus and appears to constitute a large percentage of the total dermal macrophage population. Because tissue macrophages do not always share the same immunologic repertoire as circulating monocytes/macrophages, we became interested in examining the functional immunologic capabilities of this dermal dendritic macrophage. A procedure was developed to isolate and partially purify these cells from normal human newborn foreskin, Preliminary findings are compatible with the possibility that these cells possess the capacity to present alloantigens to CD4+T cells. The potential immunologic function of this dermal perivascular macrophage is discussed in the context of its possible interactions with the other cellular components of the dermal microvascular unit (i.e., microvascular endothelial cells, perivascular T cells, and mast cells).J Invest Dermatol 93:96S–101S, 1989