The diagnostic value of plasma exosomal hsa_circ_0070396 for hepatocellular carcinoma
The diagnostic value of plasma exosomal hsa_circ_0070396 for hepatocellular carcinoma
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血浆外泌体hsa_circ_0070396对肝细胞癌的诊断价值
DOI：
10.2217/bmm-2020-0476
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发表时间：
2021-03-05
影响因子：
2.2
通讯作者：
Guo, Wei
中科院分区：
文献类型：
--
作者：
Lyu, Lihua;Yang, Wenjing;Guo, Wei
目的：我们旨在鉴定新的外泌体环状rna用于肝细胞癌（HCC）的诊断。材料与方法：提取外泌体并进行表征。通过实时荧光定量PCR验证外泌体环状rna的表达水平。根据受试者工作特征曲线分析评价候选环状rna的诊断价值。结果：外泌体circ_0070396在HCC患者中显著高于其他对照组，在区分HCC患者和健康供体方面优于甲胎蛋白。上述两种标记的结合发挥了更大的诊断性能。外泌体circ_0070396可以区分HCC患者与慢性乙型肝炎和肝硬化患者。有趣的是，外泌体circ_0070396与HCC进展呈正相关。结论：外泌体circ_0070396可能是HCC检测和治疗的潜在生物标志物。
Aim: We aimed to identify novel exosomal circular RNAs for hepatocellular carcinoma (HCC) diagnosis. Materials & methods: Exosomes were extracted and characterized. The expression level of exosomal circRNAs were verified via quantitative real-time PCR. The diagnostic value of candidate circRNAs was evaluated according to the receiver operating characteristic curve analysis. Results: The exosomal circ_0070396 significantly elevated in HCC patients than other control groups and it performed better in distinguishing HCC patients from healthy donors than that of alpha-fetoprotein. Combination of two above markers exerted greater diagnostic performance. Exosomal circ_0070396 could discriminate HCC individuals from patients with chronic hepatitis B and liver cirrhosis. Intriguingly, exosomal circ_0070396 was positively correlated with HCC progression. Conclusion: Exosomal circ_0070396 may be a potential biomarker for HCC detection and management.