Patterns of mood changes throughout the reproductive cycle in healthy women without premenstrual dysphoric disorders
Patterns of mood changes throughout the reproductive cycle in healthy women without premenstrual dysphoric disorders
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DOI：
10.1016/j.pnpbp.2008.07.016
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发表时间：
2008-12-12
影响因子：
5.6
通讯作者：
Bagdy, G.
中科院分区：
文献类型：
--
作者：
Gonda, X.;Telek, T.;Bagdy, G.
目的：女性生殖功能的周期性是生命的自然组成部分，伴随着几种生理和心理现象的变化。我们的研究的目的是调查整个女性生殖周期的心理症状的波动在健康，非PMDD（经前焦虑障碍）women.Method：63精神健康，非PMDD妇女正常规律的月经周期，不使用激素避孕方法参加了这项研究。参与者每晚完成PRISM（月经症状的影响和严重程度的前瞻性记录）日历，持续三个周期，此外，他们还在第一个周期的三个预定日完成了其他几项心理测量（症状困扰检查表-SCL-51，状态特质焦虑量表-STAI，Zung抑郁自评量表-EADS，饮食态度测试-EAT，身心宣泄量表）。根据PRISM上从卵泡晚期到黄体晚期身体症状至少增加66%，将受试者分配到黄体期身体症状（LPPS）组和无黄体期身体症状（nonLPPS）组。心理测量分数与周期内的时间和身体symptoms.Results：心理测量分数随时间的显着变化，观察到STAI状态焦虑，SCL焦虑，SCL躯体化，SCL抑郁，SCL强迫，SCL人际关系敏感，SCL总，和OHSS。SCL躯体化分量表和SCL-90量表的时间× LPPS分组交互作用显著。LPPS分组仅与SCL 51中的人际敏感分量表相关。结论：在健康的非PMDD女性人群中，从卵泡晚期到黄体晚期，与神经质和抑郁相关的心理症状显著增加。虽然我们的结果可能没有直接的临床意义。因为心理测量分数的统计学显著增加仍然很小。一个重要的发现是，在女性生殖周期中，心理症状的波动有一个可观察到的一致模式。(c)2008年爱思唯尔公司All rights reserved.
Objective: The cyclic nature of female reproductive function is a natural part of life accompanied by changes in several physical and psychological phenomena. The aim of our study was to investigate the fluctuation of psychological symptoms throughout the female reproductive cycle in healthy, non-PMDD (premenstrual dysphoric disorder) women.Method: 63 psychiatrically healthy, non-PMDD women with normal regular menstrual cycles and not using hormonal contraceptive methods participated in the study. Participants completed the PRISM (Prospective Record of the Impact and Severity of Menstrual Symptoms) calendar every night for three cycles and in addition they completed several other psychometric measures (Symptom Distress Checklist-SCL-51, State Trait Anxiety Inventory-STAI, Zung Self-rating Depression Scale-ZSDS, Eating Attitude Test-EAT, Mind and Body Cathexis Scale) at three predefined days of the first cycle. Based on an at least 66% increase in physical symptoms from the late follicular to the late luteal phase on the PRISM, subjects were assigned to luteal phase physical symptoms (LPPS) and no luteal phase physical symptoms (nonLPPS) groups. The association of psychometric scores with timing within the cycle and with physical symptoms was analysed.Results: Significant changes in psychometric scores over time were observed for STAI state anxiety, SCL anxiety, SCL somatization, SCL depression, SCL obsessive-compulsive, SCL interpersonal sensitivity, SCL total, and ZSDS. A significant time x LPPS grouping interaction emerged in case of the SCL somatization subscale and the ZSDS. LPPS grouping was associated with only the interpersonal sensitivity subscale of the SCL51.Conclusion: Our results indicate that there is a significant increase in psychological symptoms related to neuroticism and depression from the late follicular to the late luteal phase in a healthy, non-PMDD female population. Although our results may not have direct clinical significance. since the statistically significant increases in psychometric scores are still small. it is an important finding that there is a consistent pattern observable in the fluctuation of psychological symptoms accompanying the female reproductive cycle. (c) 2008 Elsevier Inc. All rights reserved.