Role of 4-hydroxynonenal and its metabolites in signaling
Role of 4-hydroxynonenal and its metabolites in signaling
复制标题
DOI：
10.1179/135100007x162211
复制
发表时间：
2007-02-01
期刊：
影响因子：
3.8
通讯作者：
Awasthi, Yogesh C.
中科院分区：
文献类型：
--
作者：
Dwivedi, Seema;Sharma, Abha;Awasthi, Yogesh C.
关于4-羟基壬烯醛（HNE）对细胞过程影响的大量研究的现有证据似乎集中在一些共同的主题上：（i）HNE对关键信号传导组分的浓度依赖性相反作用（例如蛋白激酶C，腺苷酸环化酶）预测正常细胞功能可能需要一定组成水平的HNE-细胞中这种组成型HNE水平的降低促进增殖机制，而这种水平的增加促进凋亡信号传导;（ii）HNE是由H2 O2、超氧化物、UV、热或氧化剂化学品如阿霉素引起的应激诱导的细胞凋亡的共同特征;和（iii）HNE可以通过膜受体如EGFR或Fas（CD 95）调节配体非依赖性信号传导，并且可以作为引起应激反应的外部刺激的传感器。在HNE在体外和体内的各种报道作用的背景下，我们批判性地评估了上述假设，表明HNE在信号传导中的关键作用。
Available evidence from a multitude of studies on the effects of 4-hydroxynonenal (HNE) on cellular processes seem to converge on some common themes: (i) concentration-dependent opposing effects of HNE on key signaling components (e.g. protein kinase C, adenylate cyclase) predict that certain constitutive levels of HNE may be needed for normal cell functions-lowering of this constitutive HNE level in cells promotes proliferative machinery while an increase in this level promotes apoptotic signaling; (ii)HNE is a common denominator in stress- induced apoptosis caused by H2O2, superoxide, UV, heat or oxidant chemicals such as doxorubicin; and (iii) HNE can modulate ligand-independent signaling by membrane receptors such as EGFR or Fas (CD95) and may act as a sensor of external stimuli for eliciting stress-response. Against a backdrop of various reported effects of HNE, in vitro and in vivo, we have critically evaluated the above mentioned hypotheses suggesting a key role of HNE in signaling.