Anti-STAT6 CTL activity in Stat6 (-/-) mice: A cautionary tale.
Anti-STAT6 CTL activity in Stat6 (-/-) mice: A cautionary tale.
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DOI：
10.4161/jkst.24554
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发表时间：
2013-04-01
期刊：
影响因子：
--
通讯作者：
Aldrich CJ
中科院分区：
文献类型：
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作者：
Kaplan MH;Cundiff JK;Smith JS;Aldrich CJ
The generation of germline gene mutations in mice has been an invaluable tool for experimental biology. However, studying immune responses that develop in the absence of a specific protein that could alter thymic selection complicates experimental interpretations. We observed that CD8+ T cells from Stat6−/− mice displayed “autoreactivity” to STAT6-expressing cells, associated with specific STAT6 peptides binding to MHC class I molecules. These results suggest caution in interpreting experiments where STAT6-expressing cells are transferred into Stat6−/− mice, or where adoptive transfer of Stat6−/− lymphocytes is performed. Our results further highlight additional considerations when studying immune responses involving cell transfer into gene-deficient mice.
