Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice
Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice
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DOI：
10.1016/s0304-3835(02)00502-5
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发表时间：
2003-01-10
期刊：
影响因子：
9.7
通讯作者：
Hill, SM
中科院分区：
文献类型：
--
作者：
Collins, A;Yuan, L;Hill, SM
MT1褪黑素受体在MCF-7人乳腺癌细胞中的过表达显著增强了这些细胞对褪黑素生长抑制作用的反应。裸鼠移植了MT1过表达的MCF-7细胞，与载体转染的MCF-7细胞(Vt-MCF-7)相比，裸鼠可触及的肿瘤显著减少(减少60%)。与接受Vt-MCF-7细胞的小鼠相比，接受MT1过表达的MCF-7细胞的小鼠的肿瘤发病率比接受Vt-MCF-7细胞的小鼠的肿瘤发病率降低了80%。有趣的是，每天服用褪黑素并没有降低接受Vt-MCF-7细胞的小鼠的肿瘤发病率，而是刺激了整体肿瘤的形成。(C)2003爱思唯尔爱尔兰科学有限公司。保留所有权利。
Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells significantly enhances the response of these cells to the growth-inhibitory actions of melatonin. Athymic nude mice implanted with MT1-overexpressing MCF-7 cells developed significantly fewer palpable tumors (60% reduction) compared to mice receiving vector-transfected MCF-7 cells (vt-MCF-7). In response to exogenous melatonin, tumor incidence in the mice receiving the MT1-overexpressing MCF-7 cells was decreased by 80% compared to mice receiving vt-MCF-7 cells. Interestingly, daily melatonin administration did not decrease tumor incidence in mice receiving vt-MCF-7 cells, but rather stimulated overall tumor formation. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.