An unexpected tail of VEGF and PlGF in pre-eclampsia
An unexpected tail of VEGF and PlGF in pre-eclampsia
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DOI：
10.1042/bst20110671
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发表时间：
2011-12-01
影响因子：
3.9
通讯作者：
Bates, David O.
中科院分区：
文献类型：
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作者：
Bates, David O.
PET（先兆子痫毒血症），其特征在于妊娠相关的高血压和蛋白尿，由于广泛的内皮功能障碍，是产妇发病的主要原因。改变的循环因子，特别是VEGF（血管内皮生长因子）蛋白质家族及其受体，被认为是这种疾病的关键因素。PET患者的血浆诱导内皮细胞的许多细胞和生理变化，表明存在正常血浆成分的循环失衡。这些已经被缩小到蛋白质和受体的VEGF家族的大分子。已经表明，完整血管中的内皮细胞对来自先兆子痫患者的血浆的反应是VEGF依赖性的。最近已经表明，这可能对VEGF（165）B同种型是特异性的，并且通过加入重组人PlGF（胎盘生长因子）来阻断。这些结果表明，sVEGFR 1（可溶性VEGF受体1）水平不足以结合来自先兆子痫患者的人血浆中的VEGF-A，并且其他循环大分子结合但不抑制VEGF-A，这表明涉及由减少或结合的PIGF或增加的sVEGFR 1增加循环血浆的生物活性引起的VEGF同种型的生物利用度改变的新假设，可以测试。这表明，知道如何改变VEGF家族成员的平衡可以防止内皮激活，并可能预防先兆子痫的一些症状。
PET (pre-eclamptic toxaemia), characterized by pregnancy-related hypertension and proteinuria, due to widespread endothelial dysfunction, is a primary cause of maternal morbidity. Altered circulating factors, particularly the VEGF (vascular endothelial growth factor) family of proteins and their receptors, are thought to be key contributors to this disease. Plasma from patients with PET induces numerous cellular and physiological changes in endothelial cells, indicating the presence of a circulating imbalance of the normal plasma constituents. These have been narrowed down to macromolecules of the VEGF family of proteins and receptors. It has been shown that responses of endothelial cells in intact vessels to plasma from patients with pre-eclampsia is VEGF-dependent. It has recently been shown that this may be specific to the VEGF(165)b isoform, and blocked by addition of recombinant human PIGF (placental growth factor). Taken together with results that show that sVEGFR1 (soluble VEGF receptor 1) levels are insufficient to bind VEGF-A in human plasma from patients with pre-eclampsia, and that other circulating macromolecules bind, but do not inactivate, VEGF-A, this suggests that novel hypotheses involving altered bioavailability of VEGF isoforms resulting from reduced or bound PIGF, or increased sVEGFR1 increasing biological activity of circulating plasma, could be tested. This suggests that knowing how to alter the balance of VEGF family members could prevent endothelial activation, and potentially some symptoms, of pre-eclampsia.