Follicular and hormonal dynamics during the estrous cycle in goats
Follicular and hormonal dynamics during the estrous cycle in goats
复制标题
DOI：
10.1262/jrd.17017
复制
发表时间：
2005-08-01
影响因子：
1.8
通讯作者：
Taya, K
中科院分区：
文献类型：
--
作者：
Medan, MS;Watanabe, G;Taya, K
对6只山羊连续3个发情周期每天进行卵巢经直肠超声检查。每天采集血液样本，测定FSH、雌二醇A和雌二醇-17 β的浓度。分析卵泡和激素数据，以了解卵泡波和激素浓度之间的关系。在排卵间期，卵泡的生长和消退呈波浪状（2-5波），以3波和4波为主。此外，在卵泡波的生长阶段，优势卵泡的直径之间没有显著差异。3 mm卵泡的数量在排卵间隔的第0、7和11天达到峰值，其中有3个卵泡波，在排卵间隔的第-1、5、11和15天达到峰值，其中有4个卵泡波。血浆FSH浓度在卵泡波出现前后升高，随卵泡生长而下降。在无排卵波中，随着优势卵泡的消退，循环FSH再次增加，而在排卵波中FSH水平仍然很低。抑制素A与FSH呈负相关，而与雌二醇-17 β呈正相关，这表明抑制素A是健康生长卵泡的产物，有助于抑制FSH分泌。山羊卵巢卵泡的生长呈波浪状，卵泡优势不明显。此外，卵泡素A可能是通过抑制山羊FSH分泌来调节卵泡波的关键激素。
Transrectal ultrasonography of ovaries was performed daily in 6 goats for 3 consecutive estrous cycles. Blood samples collected daily were measured for concentrations of FSH, inhibin A, and estradiol-17 beta. Follicular and hormonal data were analyzed for associations between the follicular waves and hormonal concentrations. During the interovulatory intervals, follicular growth and regression occurred in a wave like pattern (2-5 waves), and the predominant patterns were three and four follicular waves. In addition, there was no significant difference among the diameters of dominant follicles during the growth phase of the follicular waves. The number of 3 mm follicles peaked on days 0, 7, and 11 in interovulatory intervals that had three follicular waves and on days -1, 5, 11, and 15 in those that had four follicular waves. Plasma concentrations of FSH increased around the day of follicular wave emergence and declined with the growth of follicles. Circulating FSH increased again concomitant with regression of dominant follicles in the anovulatory wave, whereas FSH levels remained low in the ovulatory wave. Inhibin A was negatively correlated with FSH, while it was positively correlated with estradiol-17 beta, suggesting that inhibin A is a product of healthy growing follicles and that it contributes to the suppression of FSH secretion. In conclusion, the growth of ovarian follicles in goats exhibits a wave-like pattern, and follicular dominance is less apparent in goats. Moreover, inhibin A may be a key hormone for regulation of the follicular wave through suppression of FSH secretion in goats.