Correspondence between stone composition and urine supersaturation in nephrolithiasis
Correspondence between stone composition and urine supersaturation in nephrolithiasis
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DOI：
10.1038/ki.1997.126
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发表时间：
1997-03-01
影响因子：
19.6
通讯作者：
Coe, FL
中科院分区：
文献类型：
--
作者：
Parks, JH;Coward, M;Coe, FL
将来自结石病患者的三个24小时治疗前尿液样本中获得的一水草酸钙（COM）、透钙磷石（Br）和尿酸（UA）的过饱和度（SS）与相同患者排出的结石的矿物组成进行比较，以确定稀疏尿液SS测量值是否准确反映肾脏和最终尿液中的长期平均SS值。在男性和女性中，SS高于相同性别正常值的升高对应于组成。同样，降低结石率的治疗也降低了这些SS值。磷酸钙（CaP）混合物的程度准确匹配的COM和Br SS的移动幅度。此外，CaP含量的增加与尿柠檬酸盐下降和尿pH值上升有关，表明肾小管酸中毒。我们的结论是，稀疏尿SS测量准确跟踪结石混合物，是一个可靠的指标平均肾和尿SS。
Supersaturation (SS) with respect to calcium oxalate monohydrate (COM), brushite (Br) and uric acid (UA), obtained in three 24-hour pretreatment urine samples from patients with stone disease were compared to the mineral composition of stones passed by the same patients to determine whether sparse urine SS measurements accurately reflect the long-term average SS values in the kidney and final urine. Among males and females elevation of SS above same sex normals corresponded to composition. As well, treatments that reduced stone rates also reduced these SS values. The degree of calcium phosphate (CaP) admixture was accurately matched by shifting magnitudes of COM and Br SS. As well, increasing CaP content was associated with falling urine citrate and rising urine pH, suggesting renal tubular acidosis. We conclude that sparse urine SS measurements accurately track stone admixtures, and are a reliable index of average renal and urine SS.