Construction of Interglycosidic N-O Linkage via Direct Glycosylation of Sugar Oximes
Construction of Interglycosidic N-O Linkage via Direct Glycosylation of Sugar Oximes
复制标题
通过糖肟直接糖基化构建糖苷间 N-O 连接
DOI：
10.1021/ol301863j
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发表时间：
2012-08-03
期刊：
影响因子：
5.2
通讯作者：
Yu, Biao
中科院分区：
文献类型：
--
作者：
Yu, Jun;Sun, Jiansong;Yu, Biao
首次以糖基邻己炔基苯甲酸酯为供体在PPh3AuOTf催化下实现了糖肟和HONHFmoc的直接糖基化，为合成具有重大生物学意义的N-O连接糖提供了有效途径。
Direct glycosylation of sugar oximes and HONHFmoc has been realized for the first time by using glycosyl ortho-hexynylbenzoates as donors under the catalysis of PPh3AuOTf, providing an effective approach to the synthesis of N-O linked saccharides, which are of great biological interest.