Electrical localization of neural activity in the dorsal horn of the spinal cord: a modeling study.
Electrical localization of neural activity in the dorsal horn of the spinal cord: a modeling study.
复制标题
脊髓背角神经活动的电定位：建模研究。
DOI：
10.1007/s10439-004-7822-5
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发表时间：
2004
影响因子：
3.8
通讯作者：
Grill,WarrenM
中科院分区：
文献类型：
--
作者：
Moffitt,MichaelA;Grill,WarrenM
椎管内微刺激是一种引发协调运动反应以恢复功能的手段。然而，人类脊髓的神经解剖学的详细地图是缺乏的，也不清楚电极应该植入哪里。我们开发了一种电的方法来定位活跃的神经元在脊髓使用电位记录从脊髓表面。我们评估了这种定位方法使用的分析模型的脊髓和两个以前开发的逆算法（标准化的低分辨率脑电磁断层扫描（sLORETA）和局部最佳源（LOS）的方法）。结果支持电源定位作为一种可行的成像方法定位（300 μm内）脊髓中的活动神经元。当16个记录电极放置在脊髓背外侧，噪声水平为2%时，LOS法可以定位声源。当记录电极被定位在脊髓的整个圆周周围时，即使在15%的噪声下，任何一种定位方法都可以定位源。最后，定位误差对预期电极位置或正演模型的电参数的不准确性不敏感，但在一种情况下对正演模型的几何修改敏感。
Intraspinal microstimulation is a means of eliciting coordinated motor responses for restoration of function. However, detailed maps of the neuroanatomy of the human spinal cord are lacking, and it is not clear where electrodes should be implanted. We developed an electrical approach to localize active neurons in the spinal cord using potentials recorded from the surface of the spinal cord. We evaluated this localization method using an analytical model of the spinal cord and two previously developed inverse algorithms (standardized low resolution brain electromagnetic tomography (sLORETA) and a locally optimal source (LOS) method). The results support electrical source localization as a feasible imaging approach for localizing (within 300 μm) active neurons in the spinal cord. The LOS method could localize the source when 16 recording electrodes were placed on the dorsolateral aspect of the cord and the noise level was 2%. When recording electrodes were positioned around the entire circumference of the spinal cord, either localization method could localize the source, even at 15% noise. Finally, localization error was not sensitive to inaccuracies in the expected electrode positions or the electrical parameters of the forward model, but was sensitive to a geometrical modification of the forward model in one case.