Prevalence of restless legs syndrome among adults in Iceland and Sweden: Lung function, comorbidity, ferritin, biomarkers and quality of life
Prevalence of restless legs syndrome among adults in Iceland and Sweden: Lung function, comorbidity, ferritin, biomarkers and quality of life
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DOI：
10.1016/j.sleep.2010.08.006
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发表时间：
2010-12-01
期刊：
影响因子：
4.8
通讯作者：
Gislason, Thorarinn
中科院分区：
文献类型：
--
作者：
Benediktsdottir, Bryndis;Janson, Christer;Gislason, Thorarinn
目的：本研究调查了冰岛雷克雅未克和瑞典乌普萨拉普通人群中两个特征良好的随机样本中不宁腿综合征（RLS）的患病率和与各种健康变量之间的关联。方法：使用国家居民登记处，从居住在冰岛雷克雅未克（n = 939）和乌普萨拉的40岁及以上成年人中随机抽样，瑞典（n = 998）被邀请参加一项关于COPD患病率的研究（应答率分别为81.1%和62.2%）。此外，参与者还被要求回答以下问卷：国际RLS评定量表，简表-12，埃普沃思嗜睡量表，以及有关睡眠、胃食管反流、糖尿病和高血压以及药物治疗的问题。结果：RLS在雷克雅未克（18.3%）比乌普萨拉（11.5%）更常见的报告，白细胞介素-6（IL-6），C-反应蛋白（CRP）和铁蛋白测定血清。冰岛女性报告的RLS几乎是瑞典女性的两倍（24.4 vs. 13.9% p = 0.001），但冰岛男性和瑞典男性之间的RLS患病率没有差异。RLS与睡眠障碍和白天过度嗜睡密切相关。与无RLS的受试者相比，有RLS的受试者更可能是前吸烟者和当前吸烟者（p < 0.001）。呼吸道症状和气道阻塞在报告RLS的患者中更普遍，他们也估计他们的身体生活质量低于没有RLS的患者（p < 0.001）。RLS与代谢综合征的症状如高血压、肥胖、全身炎症标志物（IL-6和CRP）或心血管疾病无关。铁蛋白水平显着降低RLS参与者（p = 0.0002），但不（p = 0.07）调整后的中心，年龄，性别和吸烟history.Conclusion：不安腿综合征是两倍的冰岛妇女相比，瑞典妇女。男性没有这种差异。RLS与吸烟和呼吸道症状、肺功能下降、睡眠障碍、白天过度嗜睡和生活质量的身体方面密切相关。RLS与代谢综合征的标志物如高血压、肥胖、心血管疾病或全身炎症的标志物无关。(C)2010爱思唯尔有限公司版权所有。
Objective: This study investigates the prevalence and the association between restless legs syndrome (RLS) and a large variety of health variables in two well-characterized random samples from the general population in Reykjavik, Iceland, and Uppsala, Sweden.Methods: Using the national registries of inhabitants, a random sample from adults aged 40 and over living in Reykjavik, Iceland (n = 939), and Uppsala, Sweden (n = 998), were invited to participate in a study on the prevalence of COPD (response rate 81.1% and 62.2%). In addition, the participants were asked to answer the following questionnaires: International RLS Rating Scale, Short Form-12, the Epworth Sleepiness Scale, and questions about sleep, gastroeosophageal reflux, diabetes and hypertension, as well as pharmacological treatment. Interleukin-6 (IL-6), C-reactive protein (CRP) and ferritin were measured in serum.Results: RLS was more commonly reported in Reykjavik (18.3%) than in Uppsala (11.5%). Icelandic women reported RLS almost twice as often as Swedish women (24.4 vs. 13.9% p = 0.001), but there was no difference in prevalence of RLS between Icelandic and Swedish men. RLS was strongly associated with sleep disturbances and excessive daytime sleepiness. Subjects with RLS were more likely to be ex- and current smokers than subjects without RLS (p < 0.001). Respiratory symptoms and airway obstruction were more prevalent among those reporting RLS and they also estimated their physical quality of life lower than those without RLS (p < 0.001). RLS was not associated with symptoms of the metabolic syndrome like hypertension, obesity, markers of systemic inflammation (IL-6 and CRP) or cardiovascular diseases. Ferritin levels were significantly lower in RLS participants (p = 0.0002), but not (p = 0.07) after adjustment for center, age, sex and smoking history.Conclusion: Restless legs syndrome was twice as common among Icelandic women compared to Swedish women. No such difference was seen for men. RLS was strongly associated with smoking and respiratory symptoms, decreased lung function, sleep disturbances, excessive daytime sleepiness, and physical aspects of life quality. RLS was not associated with markers of the metabolic syndrome like hypertension, obesity, cardiovascular diseases or biomarkers of systemic inflammation. (C) 2010 Elsevier B.V. All rights reserved.