Dorsal hippocampal α7 and α4β2 nicotinic receptors and memory
Dorsal hippocampal α7 and α4β2 nicotinic receptors and memory
复制标题
DOI：
10.1016/j.brainres.2006.01.052
复制
发表时间：
2006-04-07
期刊：
影响因子：
2.9
通讯作者：
Levin, ED
中科院分区：
文献类型：
--
作者：
Nott, A;Levin, ED
尼古丁受体系统已被证明对工作记忆很重要。总的来说，尼古丁激动剂已被证明可以改善记忆，而尼古丁拮抗剂则会削弱它。尼古丁参与记忆的所有神经元底物仍有待发现。杏仁核和腹侧海马体都被发现对尼古丁参与记忆功能很重要。在杏仁基底外侧核和腹侧海马区局部注射烟碱拮抗剂甲基乌头碱(MLA)阻断α7烟碱受体和二氢β-红景天碱(dHβE)阻断α4β2尼古丁受体可损害工作记忆功能，未观察到相加效应。目前的项目评估了背侧海马区α7和α4β2烟碱受体在记忆功能中的作用。成年雌性SD大鼠在16臂放射状迷宫上进行训练。大鼠(n=10)在背侧海马区植入双侧脑管。采用重复平衡设计，分别给予大鼠急性静脉滴注去甲肾上腺素βE(0、1.69、3.38、6.75mU/侧)和MLA(6.75mU/侧)。向背侧海马区注入去氢化脱氢表雄酮和MLA显著增加了工作记忆错误。然而，当这两种药物联合服用时，效果有所减弱。在参考记忆错误或反应潜伏期方面，MLA或DHBeta E没有显著影响。这些结果证实了背侧海马区α4β2和α7烟碱型乙酰胆碱受体对食欲激发的空间认知功能的重要性。(C)2006爱思唯尔B.V.保留所有权利。
Nicotinic receptor systems have been shown to be important for working memory. In general, nicotinic agonists have been shown to improve memory, and nicotinic antagonists impair it. All of the neuronal substrates for nicotinic involvement in memory still remain to be discovered. The amygdala and ventral hippocampus have both been found to be important for nicotinic involvement in memory function. Local infusion of the nicotinic antagonist methyllycaconitine (MLA) to block alpha 7 nicotinic receptors and dihydro-beta-erythrodine (DH beta E) to block alpha 4 beta 2 nicotinic receptors into the basolateral amygdala and the ventral hippocampus have been found to impair working memory function, with no additive effects being observed. The current project assessed the roles of alpha 7 and alpha 4 beta 2 nicotinic receptors in the dorsal hippocampus for memory function. Adult female Sprague-Dawley rats were trained on the 16-arm radial maze. The rats (n = 10) had bilateral cannulae implanted into the dorsal hippocampus. The rats were given acute infusions of DH beta E (0, 1.69, 3.38, and 6.75 mu g/side) and MLA (6.75 mu g/side) alone and in combination in a repeated measures counter-balanced design. DH beta E and MLA infusion into the dorsal hippocampus significantly increased working memory errors. However, when the two drugs were given in combination, an attenuated effect was seen. No significant effects of MLA or DH beta E were seen with reference memory errors or response latency. These results confirm the importance of alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors in the dorsal hippocampus for appetitively-motivated spatial cognitive function. (c) 2006 Elsevier B.V. All rights reserved.