ANTIBODY TO EPSTEIN-BARR VIRUS-SPECIFIC DNASE AS A MARKER FOR FIELD SURVEY OF PATIENTS WITH NASOPHARYNGEAL CARCINOMA IN TAIWAN
ANTIBODY TO EPSTEIN-BARR VIRUS-SPECIFIC DNASE AS A MARKER FOR FIELD SURVEY OF PATIENTS WITH NASOPHARYNGEAL CARCINOMA IN TAIWAN
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DOI：
10.1002/jmv.1890270403
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发表时间：
1989-04-01
影响因子：
12.7
通讯作者：
YANG, CS
中科院分区：
文献类型：
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作者：
CHEN, JY;CHEN, CJ;YANG, CS
本研究以EB病毒特异性脱氧核糖核酸酶抗体作为鼻咽癌患者的血清学诊断指标，对台湾地区到政府医疗中心（GECC）进行例行健康检查的健康人和居住在鼻咽癌高发区（HRA）的人进行了血清学调查。在为期3年的前瞻性研究中，分别从GECC和HRA组收集了22，596和9，869份血清。以中和2个或2个以上单位的EBV DNA酶活性为阳性反应，GECC组和HRA组的阳性率分别为5.4%和11.92%。在抗体阳性者中，GECC组有3例NPC（检出率为0.63%），HRA组有11例NPC（检出率为1.32%）。在对1 005名抗体阳性者进行随访的第一年，又发现了一名III期患者。在HRA的12名NPC患者中，5名新诊断为II期（3名患者）和III期（2名患者）NPC。这些结果支持了以下假设，即抗EBV特异性DNA酶活性的抗体可能是检测NPC患者的有用标志物，并且它们意味着具有高水平抗EBV DNA酶活性的个体可能具有增加的NPC发展风险。
A serological survey using antibody to Epstein-Barr virus (EBV)-specific DNase activity as a marker for the identification of patients with nasopharyngeal carcinoma (NPC) has been carried out on healthy subjects who visted Government Employees'' Clinic Center (GECC) for routine health examination and on individuals residing in NPC high-risk areas (HRA) in Taiwan. During a 3-year prospective study, 22,596 and 9,869 sera were collected from the GECC and HRA groups, respectively. Taking neutralization of 2 or more units of EBV DNase activity as a positive response the positivity rates in the GECC and HRA groups were 5.4% and 11.92%, respectively. Among the antibody-positive individuals, three cases of NPC were found in the GECC group (detection rate 0.63%) and 11 in the HRA group (detection rate 1.32%). A further patient at stage III of the disease was found in the first year of following up 1,005 antibody-positive individuals. Among the 12 NPC patients in the HRA, five were newly diagnosed as having stage II (three patients) and stage III (two patients) NPC. These results support the hypothesis that antibody against EBV-specific DNase activity may be a useful marker for detection of patients with NPC, and they imply that individuals having high levels of antibody to EBV DNase activity may have an increased risk of development of NPC.