The house dust mite allergen Der p1 catalytically inactivates alpha(1)-antitrypsin by specific reactive centre loop cleavage: A mechanism that promotes airway inflammation and asthma
The house dust mite allergen Der p1 catalytically inactivates alpha(1)-antitrypsin by specific reactive centre loop cleavage: A mechanism that promotes airway inflammation and asthma
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DOI：
10.1006/bbrc.1996.0544
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发表时间：
1996-04-05
影响因子：
3.1
通讯作者：
Lomas, DA
中科院分区：
文献类型：
--
作者：
Kalsheker, NA;Deam, S;Lomas, DA
Der p1是屋尘螨（HDM）屋尘螨（Dermatophagoides pteronyssinus）的半胱氨酸蛋白酶，是HDM特应性个体中过敏性免疫应答的主要组分。最近的证据表明，半胱氨酸蛋白酶活性在疾病过程中是重要的，因为它增加了过敏原在呼吸道中的渗透性，并破坏了IgE合成的调节。在螨的粪便颗粒中发现高浓度的Der p1，这些颗粒通过呼吸道雾化和吸入。丝氨酸蛋白酶抑制剂，α（1）-抗胰蛋白酶，保护下呼吸道免受炎症期间肺中释放的蛋白酶的损伤。Der p1通过一种巯基依赖性机制催化α（1）-抗胰蛋白酶失活，这种机制涉及反应中心环的特异性裂解，我们认为这种机制在哮喘的发病机制中可能很重要。(C)北京：科学出版社. Inc.
Der p1, a cysteine proteinase derived from the house dust mite (HDM) Dermatophagoides pteronyssinus, is a major component of the allergic immune response in HDM atopic individuals. Recent evidence suggests that cysteine proteinase activity is important in the disease process as it increases the permeability of the allergen in the respiratory tract and disrupts the regulation of IgE synthesis. Der p1 is found in high concentrations in the faecal pellets of mites which are aerosolised and inhaled via the respiratory tract. The serine proteinase inhibitor, alpha(1)-antitrypsin, protects the lower respiratory tract against damage by proteinases released in the lung during inflammation. Der p1 catalytically inactivates alpha(1)-antitrypsin by a thiol-dependent mechanism involving specific cleavage of the reactive centre loop and we propose that this mechanism may be important in the pathogenesis of asthma. (C) 1996 Academic Press. Inc.