Vascular distribution of nanomaterials.
Vascular distribution of nanomaterials.
复制标题
纳米材料的血管分布。
DOI：
10.1002/wnan.1271
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Nurkiewicz,TimothyR
中科院分区：
文献类型：
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作者：
Stapleton,PhoebeA;Nurkiewicz,TimothyR
曾经被认为主要是职业性的、新颖的纳米技术创新和应用导致了国内的广泛使用和有意的生物医学暴露。随着这些令人振奋的进展，毒理学考虑的广度和深度也必须扩大。血管系统与体内的每一种组织相互作用，努力维持体内平衡。工程纳米材料(ENM)已被报道分布在许多不同的组织和器官中。然而，这些观察倾向于使用需要组织均质化和/或大体器官分析的方法。这些技术虽然在确定存在方面是有效的，但排除了准确确定ENM在组织内的沉积位置的可能性。如果纳米技术要充分发挥其潜力，就有必要确定ENM在心血管系统中的准确分布和沉积，包括血管血流动力学和活体ENM修饰。血管系统的不同水平首先将被描述为单独的间隔。然后，血管系统将被视为一个整体。这些独特的隔室和生物物理条件将根据它们有利于ENM沉积的倾向进行讨论。了解血管系统的水平也将被讨论。最终，未来的研究必须验证所推测和提出的机制。这篇文章被归类为：心血管疾病的治疗方法和药物发现；纳米药物的毒理学和调控问题&纳米材料的毒理学
Once considered primarily occupational, novel nanotechnology innovations, and applications have led to widespread domestic use and intentional biomedical exposures. With these exciting advances, the breadth and depth of toxicological considerations must also be expanded. The vascular system interacts with every tissue in the body, striving to maintain homeostasis. Engineered nanomaterials (ENM) have been reported to distribute in many different tissues and organs. However, these observations have tended to use approaches requiring tissue homogenization and/or gross organ analyses. These techniques, while effective in establishing presence, preclude an exact determination of where ENM are deposited within a tissue. If nanotechnology is to achieve its full potential, it is necessary to identify this exact distribution and deposition of ENM throughout the cardiovascular system, with respect to vascular hemodynamics andin vivoENM modifications taken into account. Distinct levels of the vasculature will first be described as individual compartments. Then the vasculature will be considered as a whole. These unique compartments and biophysical conditions will be discussed in terms of their propensity to favor ENM deposition. Understanding levels of the vasculature will also be discussed. Ultimately, future studies must verify the mechanisms speculated on and presented herein.This article is categorized under:Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular DiseaseToxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials