Punctate Inner Choroidopathy Clinical Features and Outcomes
Punctate Inner Choroidopathy Clinical Features and Outcomes
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DOI：
10.1001/archophthalmol.2010.157
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发表时间：
2010-08-01
影响因子：
--
通讯作者：
Dowler, Jonathan
中科院分区：
文献类型：
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作者：
Essex, Rohan W.;Wong, James;Dowler, Jonathan
目的：描述一大群患者的临床表现谱和诊断为点状内部脉络膜病变（PIC）的临床特征和结果：在一个回顾性的连续病例系列，在16年期间在Moorfields眼科医院谁被诊断为PIC，并有至少12个月的随访患者被纳入。患者被分为典型PIC或非典型PIC（较大的，推测为眼部组织胞浆菌病综合征样病变）。主要观察指标包括脉络膜新生血管的发展，新的PIC病变的发展，和最终视力。平均年龄为32岁，126例患者（93%）为女性，平均屈光度为-4.6屈光度。总体平均随访时间为6.2年。在63只正常对侧眼中，56只（88%）保持不变，3只（5%）发展为PIC病变，4只（6%）发展为脉络膜新生血管。在74例患者中，49例（66%）有PIC病变的眼睛保持不变，9例（12%）发生新的PIC病变，16例（22%）发生脉络膜新生血管膜。在患有脉络膜新生血管的眼睛中，研究入组时的平均logMAR视力为0.63，12个月时为0.63，2年时为0.61，最终审查时为0.71（平均6.1年）。总体而言，40只患PIC相关脉络膜新生血管膜的眼睛（26%）的最终视力低于6/60。在任何结果测量或任何亚组analysis.Conclusions：点状内部脉络膜病变相关的脉络膜新生血管在视觉上不是良性的，没有观察到典型和非典型PIC眼睛之间的差异。在具有典型和非典型脉络膜病变的眼睛之间没有观察到差异，这支持了它们代表单一疾病（PIC）谱的观点。
Objective: To describe the clinical features and outcomes of a large group of patients with a spectrum of clinical appearances and diagnosed as having punctate inner choroidopathy (PIC).Methods: In a retrospective consecutive case series, patients seen during a 16-year period at Moorfields Eye Hospital who were diagnosed as having PIC and had a minimum of 12 months' follow-up were included. Patients were classified as having typical PIC or atypical PIC (larger, presumed ocular histoplasmosis syndrome like lesions). Main outcome measures included development of choroidal neovascularization, development of new PIC lesions, and final visual acuity.Results: A total of 136 patients (271 eyes) were included. The average age was 32 years, 126 patients (93%) were female, and the mean refraction was -4.6 diopters. The overall mean follow-up was 6.2 years. Among 63 normal fellow eyes, 56 (88%) remained unchanged, 3 (5%) developed PIC lesions, and 4 (6%) developed choroidal neovascularization. Eyes with PIC lesions remained unchanged in 49 of 74 cases (66%), with 9 (12%) developing new PIC lesions and 16 (22%) developing choroidal neovascular membrane. In eyes with choroidal neovascularization, the mean logMAR visual acuity was 0.63 at study entry, 0.63 at 12 months, 0.61 at 2 years, and 0.71 at final review (mean, 6.1 years). Overall, 40 eyes with PIC-related choroidal neovascular membrane (26%) had final visual acuity less than 6/60. No differences were observed between typical and atypical PIC eyes in any of the outcome measures or in any of the subgroup analyses.Conclusions: Punctate inner choroidopathy related choroidal neovascularization was not visually benign. No differences were observed between eyes with typical and atypical choroidal lesions, supporting the notion that they represent a spectrum of a single disease, PIC.