High-density lipoprotein cholesterol and apolipoprotein A1 levels strongly influence the reactivity of small peripheral arteries
High-density lipoprotein cholesterol and apolipoprotein A1 levels strongly influence the reactivity of small peripheral arteries
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DOI：
10.1016/j.atherosclerosis.2011.01.039
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发表时间：
2011-05-01
期刊：
影响因子：
5.3
通讯作者：
Masana, Luis
中科院分区：
文献类型：
--
作者：
Ferre, Raimon;Aragones, Gemma;Masana, Luis
目的：切变后反应性充血是内皮功能的替代指标。然而，控制外周小阻力动脉扩张能力的机制尚未很好地表征。我们通过外周动脉血压计（PAT）评估了肢端动脉的反应性充血，并研究了其临床和生化决定因素。方法：共招募了816名具有中高心血管风险的受试者。采用PAT法测定手指小动脉反应性充血指数（RHI）。并对临床病史、人体测量及生化指标进行分析。我们研究了临床和生化因素与小动脉RHI的关系。结果：高密度脂蛋白胆固醇和载脂蛋白A1水平与舒张反应增加密切直接相关。代谢综合征的组成部分，如腰围增加、高甘油三酯血症和吸烟，与RHI呈负相关，血清炎症标志物也是如此。外周小动脉RHI的预测因子是具有保护作用的高密度脂蛋白胆固醇和具有负面影响的吸烟。结论：高密度脂蛋白胆固醇和载脂蛋白A1水平与小动脉反应性充血呈强正相关，而吸烟、腰围和甘油三酯水平呈负相关。高密度脂蛋白胆固醇是外周小阻力动脉RHI的主要决定因素。2011爱思唯尔爱尔兰有限公司版权所有。
Objective: Reactive hyperaemia after shear stress is a surrogate marker of endothelial function. However, the mechanisms controlling the dilation capacity of small peripheral resistance arteries are not well characterised. We evaluated reactive hyperaemia by peripheral artery tonometry (PAT) in the acral arteries and studied their clinical and biochemical determinants.Methods: Eight hundred sixteen subjects at intermediate to high cardiovascular risk were recruited. The reactive hyperaemia index (RHI) of small digital arteries was measured by PAT. Clinical history data, anthropometry and biochemical parameters were also analysed. We studied the associations between clinical and biochemical factors and small artery RHI.Results: HDL cholesterol and apolipoprotein A1 levels were strongly and directly correlated with an increased dilation response. Metabolic syndrome components, such as increased waist circumference, hypertriglyceridaemia and smoking, were inversely associated with RHI as were serum markers of inflammation. The predictors of small peripheral artery RHI were HDL cholesterol, which had a protective effect, and smoking, which had a negative impact.Conclusion: HDL cholesterol and apolipoprotein A1 levels had a strong, positive correlation with small artery reactive hyperaemia, whereas smoking, waist circumference and triglyceride levels were inversely associated. HDL cholesterol was the main determinant of RHI in small peripheral resistance arteries. (C) 2011 Elsevier Ireland Ltd. All rights reserved.