What's New in Shock, November 2017?
What's New in Shock, November 2017?
复制标题
2017 年 11 月《震撼》有哪些新内容？
DOI：
10.1097/shk.0000000000000953
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Karlstad,MichaelD
中科院分区：
文献类型：
--
作者：
Collier,JJason;Burke,SusanJ;Karlstad,MichaelD
《休克》杂志的使命是“促进和促进实验和临床性质的多学科研究，批判性地研究休克相关病理生理条件的病因、机制和新疗法”。本月的期刊包含一系列出版物，包括两篇综述文章，五项基础科学研究和六项临床研究，这表明该杂志对上述使命的承诺。为了帮助我们的读者，每个出版物是简要解构在本月版本的''什么是新的''摘要格式。由于受伤是死亡的主要原因，Liu和Salinas（1）提出了一项关于使用机器学习作为技术工具的综述，以帮助创伤中心和其他医疗保健提供者提供额外的资源来提高患者护理的质量。机器学习是计算机科学和人工智能研究领域的一个分支，其中软件旨在评估输入的数据，目的是通过训练计算机“学习”特定的趋势和模式来改善预测结果。作者指出，机器学习模型可能比其他评估方法更客观。然而，由于缺乏软件标准化以及需要对医疗保健提供者进行使用这些方法的培训，这些方法处于起步阶段。虽然目前还不清楚机器学习是否会在重症监护、创伤和其他医疗保健学科中被广泛接受，但这篇综述提供了一个坚实的框架，开始这样的讨论。詹森等人(2)本书对硫化氢（H2S）在生物过程中的作用进行了令人信服的简明描述，重点放在缺血及其相关病理过程中的硫化氢分子上。H2S是一种信号分子，属于“气体传递素”家族，其中还包括一氧化碳和一氧化氮。作者讨论了H2S的内源性生产与一个很好的示意图显示酶促合成。信号，毒性，catastrophic，并提出了行动机制都包括在内。这篇综述的一个有趣的组成部分是包括用于检测这种分子的各种方法，这对基础研究和临床实验室都是有益的。最后，简要讨论了使用H2S作为缺血的可能治疗策略的各种方法，总结了未来的方向和测量H2S存在的一些固有缺陷。(3)主要关注一项研究人群的过敏相关事件，该研究人群始于17年期间在台湾接受治疗的22，080，199例台湾受试者。在2005年至2012年期间发生的2，289起过敏性休克事件中，2，219名参与者符合数据分析的入选标准。作者分析了因食物相关过敏性休克或药物诱导过敏性休克而入院的受试者的数据。数据显示，药物与台湾受试者中因过敏性休克而死亡的人数更多有关。作者指出，速发型过敏反应的临床指标存在偏差，以及临床平台之间诊断定义的差异。重要的是，这项流行病学研究增加了必要的数据，并引起了对这种免疫现象的关注。Soussi等人(4)在接下来的研究中，提出了一个有趣而重要的临床问题，即通过临床实践中常用的两种方法获得的耗氧量测量值的可重复性。氧气消耗量的准确测量非常重要，因为它通常用于...
The mission of the journal SHOCK is ‘‘to foster and promote multidisciplinary studies, both experimental and clinical in nature, that critically examine the etiology, mechanisms and novel therapeutics of shock-related pathophysiological conditions.’’This month’s issue contains a series of publications, comprising two review articles, five basic science studies, and six clinical studies, which demonstrates the journal’s commitment to the above-stated mission. For the assistance of our readership, each publication is briefly deconstructed in this month’s version of the ‘‘What’s New’’summary format. With injury as a leading cause of death, Liu and Salinas (1) have put forth a review on the use of machine learning as a technological tool to assist trauma centers and other health care providers with an additional resource to enhance the quality of patient care. Machine learning is a branch of the computer science and artificial intelligence research areas where software is designed to assess data that have been input with the goal of improving predictive outcomes due to training the computer to ‘‘learn’’specific trends and patterns. The authors point out that machine learning models could be more objective than other methods of evaluation. However, these methods are in their infancy due to lack of software standardization as well as the need for health care provider training in the use of such methods. Although it is unclear at the present time whether machine learning will be widely accepted in critical care, trauma, and other health care disciplines, this review provides a solid framework from which to begin such discussion. Jensen et al.(2) assembled a cogent and concise description of hydrogen sulfide (H2S) in biological processes, with an emphasis on this molecule during ischemia and its associated pathologies. H2S is a signaling molecule that fits within the ‘‘gasotransmitter’’family, which also includes carbon monoxide and nitric oxide. The authors discuss the endogenous production of H2S with an excellent schematic showing enzymatic synthesis. Signaling, toxicity, catabolism, and proposed mechanisms of action are all covered. An interesting component of this review is the inclusion of the various methodologies used for detection of this molecule, which is informative for both basic research and clinical laboratories. Finally, there is a succinct discussion of the various ways to use H2S as a possible therapeutic strategy for ischemia with a summary of future directions and some of the inherent flaws that exist for measuring H2S.The study by Liu et al.(3) is focused on anaphylaxis-related events on a study population that started with 22,080,199 Taiwanese subjects admitted into care in Taiwan over a 17-year period. Of the 2,289 anaphylactic shock episodes occurring between 2005 and 2012, 2,219 participants met the inclusion criteria for data analysis. The authors parsed the data into subjects admitted for food-related anaphylactic shock or druginduced anaphylactic shock. The data revealed that pharmaceuticals were linked with more fatalities due to anaphylactic shock in Taiwanese subjects. The authors note that there is deviation in clinical indicators of anaphylaxis, as well as variances with diagnostic definitions across clinical platforms. Importantly, this epidemiological study adds essential data and brings attention to this immunological phenomenon. Soussi et al.(4), in the next study, asked the interesting and important clinical question related to the interchangeability of oxygen consumption measurements obtained by two methods commonly used in clinical practice. The accurate measurement of oxygen consumption is important because it is often used to …