Stronger Neo‐Minophagen C™, a glycyrrhizin‐containing preparation, protects liver against carbon tetrachloride‐induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein
Stronger Neo‐Minophagen C™, a glycyrrhizin‐containing preparation, protects liver against carbon tetrachloride‐induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein
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DOI：
10.1111/j.1478-3231.2007.01492.x
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发表时间：
2007-08
影响因子：
6.7
通讯作者：
I. Hidaka;K. Hino;M. Korenaga;T. Gondo;S. Nishina;Miye Ando;M. Okuda;I. Sakaida
中科院分区：
文献类型：
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作者：
I. Hidaka;K. Hino;M. Korenaga;T. Gondo;S. Nishina;Miye Ando;M. Okuda;I. Sakaida
背景/目的：含甘草酸苷的强新米诺芬C™(SNMC)在日本用于治疗慢性肝炎已有30多年的历史，并被证明能有效地预防慢性丙型肝炎患者的肝细胞癌的发展，但其潜在的机制仍不清楚。本研究的目的是探讨SNMC是否具有抗氧化作用，因为氧化应激被认为是丙型肝炎病毒(HCV)相关性慢性肝病肝损伤的机制之一。
Background/Aim: Stronger Neo‐Minophagen C™ (SNMC), a glycyrrhizin‐containing preparation, has been used as a treatment for chronic hepatitis for more than 30 years in Japan, and shown to be effective in preventing the development of hepatocellular carcinoma in chronic hepatitis C patients, but its underlying mechanisms remain elusive. The aim of this study was to investigate if SNMC had an anti‐oxidative effect, as oxidative stress has been proposed to be one of the mechanisms of liver injury in hepatitis C virus (HCV)‐associated chronic liver diseases.