Fibroblast growth factor-23 and interleukin-6 are risk factors for left ventricular hypertrophy in peritoneal dialysis patients
Fibroblast growth factor-23 and interleukin-6 are risk factors for left ventricular hypertrophy in peritoneal dialysis patients
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DOI：
10.2459/jcm.0b013e3283536859
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发表时间：
2012-09-01
影响因子：
3
通讯作者：
He, Nan
中科院分区：
文献类型：
--
作者：
Liu, Wei-hua;Zhou, Qiao-ling;He, Nan
背景左心室肥厚（LVH）是透析患者心血管死亡的主要危险因素。方法测定62例持续性非卧床腹膜透析（CAPD）患者和30例健康对照者血清FGF-23、IL-6水平及相关实验室指标，探讨FGF-23、IL-6与CAPD患者左室肥厚的关系。结果CAPD患者血清FGF-23和IL-6水平均显著高于健康对照组，伴LVH患者血清FGF-23和IL-6水平均显著高于无LVH患者。发现FGF-23与左心室质量指数（LVMI）和血磷呈正相关。IL-6水平与LVMI呈正相关，与血清白蛋白、血红蛋白呈负相关。结论FGF-23和IL-6是CAPD患者LVH发生的独立危险因素，且二者共同参与CAPD患者LVH的发生。
Background Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular death in dialysis patients. Fibroblast growth factor-23 (FGF-23) and interleukin-6 (IL-6) were thought to be related to cardiovascular diseases (CVDs) in dialysis.Methods To determine the relationship between FGF-23, IL-6 and LVH in continuous ambulatory peritoneal dialysis (CAPD) patients, serum FGF-23 and IL-6 levels as well as standard laboratory parameters were assessed in 62 CAPD patients and 30 healthy controls. LVH was determined by echocardiography in dialysis patients.Results Serum FGF-23 and IL-6 levels were significantly higher in CAPD patients than in healthy controls, whereas both were higher in patients with LVH than in patients without LVH. FGF-23 was found to be positively associated with left ventricle mass index (LVMI) and serum phosphate. IL-6 level was positively associated with LVMI and negatively correlated with serum albumin and hemoglobin. Serum FGF-23 level was positively correlated with IL-6 level.Conclusion FGF-23 and IL-6 are independent risk factors for LVH in CAPD patients and both collaborated in causing LVH in CAPD.