Intergenerational transmission of health disparities among Turkish-origin immigrants in Germany: study protocol of a multi-centric cohort study (BaBi-stress and BaBeK study)
Intergenerational transmission of health disparities among Turkish-origin immigrants in Germany: study protocol of a multi-centric cohort study (BaBi-stress and BaBeK study)
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DOI：
10.1186/s12884-020-2853-y
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发表时间：
2020-03-12
影响因子：
3.1
通讯作者：
Entringer, Sonja
中科院分区：
文献类型：
--
作者：
Spallek, Jacob;Scholaske, Laura;Entringer, Sonja
与非移民人口相比，德国的移民表现出更高的社会劣势。土耳其裔移民是德国一个重要的移民群体，从出生开始在某些健康领域就表现出明显的差异。几项研究表明，社会劣势在生物学上是如何影响一生健康的。然而，对于母亲的社会状况是否以及如何传递给下一代，人们仍然知之甚少。因此，本研究旨在分析母亲的社会经济地位和移民身份对怀孕期间与压力相关的母-胎盘-胎儿（MPF）生物学过程对婴儿出生和健康结局的影响。方法本纵向队列研究在德国的两个研究地点对N = 144对母子进行研究，包括居住在德国的土耳其裔孕妇和德国孕妇。在怀孕期间，对母亲血液和唾液样本中的强积金压力生物学标记、母亲的社会经济和移民相关信息、医疗风险变量和心理健康进行评估。出生后，对婴儿的人体测量和发育结果进行评估。根据与伊斯坦布尔BABIP的合作研究，将在土耳其孕妇中评估相同的措施并与之进行比较。这是关于德国健康差异代际传递的第一项研究，重点是土耳其裔妇女。该研究面临着与其他出生队列相似的偏倚风险。本研究实施了各种措施，例如，具有文化敏感性的招募策略，尝试招募和跟踪尽可能多的孕妇，而不受其社会或文化背景的影响。然而，受教育程度较低的家庭的回复率较低。将结果与来自土耳其的队列进行比较的可能性是本研究的优势。然而，在不同的时间开始，招聘策略和设计略有不同，可能会导致队列效应，并可能影响子队列的可比性。
Background Immigrants in Germany exhibit higher levels of social disadvantage when compared to the non-immigrated population. Turkish-origin immigrants constitute an important immigrant group in Germany and show disparities in some health domains that are evident from birth onwards. Several studies have shown the mechanisms by which social disadvantage is biologically embedded to affect health over the lifespan. Relatively little, however, is still known about if and how the maternal social situation is transmitted to the next generation. This study therefore aims to analyse the effects of maternal socioeconomic status and migration status on stress-related maternal-placental-fetal (MPF) biological processes during pregnancy on infant birth and health outcomes. Methods This longitudinal cohort study of N = 144 child-mother dyads is located at two study sites in Germany and includes pregnant women of Turkish origin living in Germany as well as pregnant German women. During pregnancy, MPF stress biology markers from maternal blood and saliva samples, maternal socio-economic and migration-related information, medical risk variables and psychological well-being are assessed. After birth, infant anthropometric measures and developmental outcomes are assessed. The same measures will be assessed in and compared to Turkish pregnant women based on a collaboration with BABIP study in Istanbul. Discussion This is the first study on intergenerational transmission of health disparities in Germany with a focus on women of Turkish-origin. The study faces similar risks of bias as other birth cohorts do. The study has implemented various measures, e.g. culturally sensitive recruitment strategies, attempt to recruit and follow-up as many pregnant women as possible independent of their social or cultural background. Nevertheless, the response rate among lower-educated families is lower. The possibility to compare results with a cohort from Turkey is a strength of this study. However, starting at different times and with slightly different recruitment strategies and designs may result in cohort effects and may affect comparability of the sub-cohorts.