Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension.
Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension.
复制标题
DOI：
10.1161/hypertensionaha.121.14519
复制
发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Gumz ML
中科院分区：
文献类型：
--
作者：
Costello HM;Gumz ML
越来越多的证据表明，分子生物钟在血压（BP）控制中至关重要。昼夜节律由位于下丘脑视交叉上核（SCN）的中央时钟和遍布全身的外周时钟控制。光线和食物的线索都能影响这些生物钟，但这些线索是否对BP的昼夜节律很重要，这是一个越来越受关注的领域。平滑肌、血管周围脂肪组织、肝脏、肾上腺和肾脏中的外周生物钟最近被认为与血压节律的调节有关。血压昼夜节律失调与不良心肾结局和心血管死亡风险增加相关。在这篇综述中，我们总结了外周生物钟作为血压调节器的最新进展，强调了高血压昼夜血压节律紊乱的不良后果，并提供了深入了解未来潜在的工作领域探索生物钟在血压控制和时间疗法。更好地了解外周生物钟在调节血压昼夜节律中的作用，将有助于为血压昼夜节律失调和高血压的靶向治疗铺平道路。
Accumulating evidence suggests that the molecular circadian clock is crucial in blood pressure (BP) control. Circadian rhythms are controlled by the central clock, which resides in the suprachiasmatic nucleus (SCN) of the hypothalamus, and peripheral clocks throughout the body. Both light and food cues entrain these clocks but whether these cues are important for the circadian rhythm of BP is a growing area of interest. The peripheral clocks in the smooth muscle, perivascular adipose tissue, liver, adrenal gland, and kidney have been recently implicated in the regulation of BP rhythm. Dysregulation of the circadian rhythm of BP is associated with adverse cardiorenal outcomes and increased risk of cardiovascular mortality. In this review, we summarize the most recent advances in peripheral clocks as BP regulators, highlight the adverse outcomes of disrupted circadian BP rhythm in hypertension, and provide insight into potential future work in areas exploring the circadian clock in BP control and chronotherapy. A better understanding of peripheral clock function in regulating the circadian rhythm of BP will help pave the way for targeted therapeutics in the treatment of circadian BP dysregulation and hypertension.