Adaptive changes in trabecular architecture in relation to functional strain patterns and disuse
Adaptive changes in trabecular architecture in relation to functional strain patterns and disuse
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DOI：
10.1016/8756-3282(96)00116-0
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发表时间：
1996-07-01
期刊：
影响因子：
4.1
通讯作者：
Baudinette, RV
中科院分区：
文献类型：
--
作者：
Biewener, AA;Fazzalari, NL;Baudinette, RV
在跑步机运动和通过跟腱施加张力的情况下，通过对兔（一种小型有袋动物）跟骨外侧皮质表面记录的体内和原位应变来确定主应变及其方向，并将其与潜在的小梁结构及其对齐进行比较，以验证Wolff小梁对齐的“轨迹理论”。体内和原位主压缩应变（-800至-2000 μ e）被发现与跟骨干骺端下小梁的首选对齐（平均161 +/- 7度）接近（160度）[第二个小梁拱道与主拉伸应变的方向（71度）紧密对齐（70度）]，这一发现代表了Wolff小梁对齐轨迹理论的定量验证。这些小梁排列，由小梁各向异性（TbAn）测量，水平：然而，与对侧对照相比，肌腱切断的跟骨骨小梁体积分数（BV/TV, -35%）、小梁厚度（TbTh, -25%）和小梁数量（TbN, -16%）减少（p < 0.001至< 0.003），小梁数量的减少与小梁间距的相应增加相关（Tbsp, +30%）。这些结果表明，在生长过程中，小梁排列一旦建立（在运动过程中沿着主应变方向），当去除功能应变时，小梁排列不会改变。
Principal strains and their orientation, determined from in vivo and in situ strains recorded from the lateral cortical surface of the calcaneus of potoroos (a small marsupial) during treadmill exercise and tension applied via the Achilles tendon, were compared with the underlying trabecular architecture and its alignment to test Wolff's ''trajectorial theory'' of trabecular alignment, In vivo and in situ principal compressive strains (-800 to -2000 mu e) were found to be aligned (mean 161 +/- 7 degrees) close to the preferred alignment (160 degrees) of underlying trabeculae within the calcaneal metaphysis [a second trabecular arcade was closely aligned (70 degrees) with the direction (71 degrees) of principal tensile strain], This finding represents quantitative verification of Wolff's trajectorial theory of trabecular alignment. These trabecular alignments, as measured by trabecular anisotropy (TbAn, the ratio of horizontal: vertical intercepts), remained unchanged (p > 0.05) after 8 weeks of disuse, However, trabecular bone volume fraction (BV/TV, -35%), trabecular thickness (TbTh, -25%), and trabecular number (TbN, -16%) were reduced for the tenotomized calcaneii relative to their contralateral controls (p < 0.001 to < 0.003), The reduction in trabecular number was associated with a corresponding increase in trabecular spacing (Tbsp, +30%), Together, these results suggest that once trabecular alignment is established during growth (along the directions of principal strain during locomotion), it is not altered when functional strains are removed.