Epidemiology of enterotoxigenic Escherichia coli diarrhea in a pediatric cohort in a periurban area of lower Egypt.-猫眼课题宝

DOI：

10.1086/314593

发表时间：

1999-02

期刊：

The Journal of infectious diseases

影响因子：

通讯作者：

中科院分区：

其他

文献类型：

作者：

R. Abu-Elyazeed;T. Wierzba;A. Mourad;L. Peruski;B. Kay;M. Rao;A. Churilla;A. L. Bourgeois;A. Mortagy;S. Kamal;S. Savarino;James R. Campbell;J. Murphy;A. Naficy;J. Clemens

产肠毒素大肠杆菌（ETEC）是表达热不稳定（LT）和/或热稳定（ST）肠毒素的多种病原体，但对儿科ETEC腹泻的流行病学模式是否因表达的ETEC毒素表型而异知之甚少。1993-1995年，总共对242名3岁以下的埃及儿童进行了前瞻性跟踪。在每周两次的家庭访视中检测到ETEC发作，并从每月的横断面调查中确定无症状ETEC排泄。ETEC事件为0.6/儿童年。仅ST的ETEC在温暖的月份比凉爽的月份多2.6倍（P<.001），而仅LT的ETEC没有季节性变化。拥有一个家庭卫生厕所，但不是母乳喂养，与两种肠毒素表型的风险较低。仅LT或ST的ETEC共表达定植因子加强了与腹泻的相关性。这些结果表明，仅LT和仅ST ETEC的流行病学模式并不相同，疾病干预措施应包括改善家庭卫生。

Enterotoxigenic Escherichia coli (ETEC) are diverse pathogens that express heat-labile (LT) and/or heat-stable (ST) enterotoxins, yet little is known about whether epidemiologic patterns of pediatric ETEC diarrhea vary by the expressed ETEC toxin phenotype. In total, 242 Egyptian children aged <3 years were prospectively followed in 1993-1995. ETEC episodes were detected during twice-weekly home visits, and asymptomatic ETEC excretion was identified from monthly cross-sectional surveys. ETEC episodes were 0.6 per child-year. ST-only ETEC was 2.6 times (P<.001) more common in warmer than cooler months, while LT-only ETEC showed no seasonal variation. Ownership of a household sanitary latrine, but not breast-feeding, was associated with a lower risk of both enterotoxin phenotypes. Coexpression of a colonization factor by LT- or ST-only ETEC strengthened the association with diarrhea. These findings indicate that the epidemiologic patterns of LT-only and ST-only ETEC are not identical and that disease interventions should include improved household sanitation.

Epidemiology of enterotoxigenic Escherichia coli diarrhea in a pediatric cohort in a periurban area of lower Egypt.

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