Dietary sugar and lung cancer: A case-control study in Uruguay
Dietary sugar and lung cancer: A case-control study in Uruguay
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DOI：
10.1080/01635589809514692
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发表时间：
1998-01-01
影响因子：
2.9
通讯作者：
Carzoglio, JC
中科院分区：
文献类型：
--
作者：
De Stefani, E;Deneo-Pellegrini, H;Carzoglio, JC
为了研究饮食中的糖是否会改变肺癌风险，在1993-1996年间，乌拉圭进行了一项病例对照研究，涉及463名肺癌患者和465名住院对照。饮食模式的详细评估使用了食物频率调查问卷，该问卷允许计算总能量摄入量。通过包括吸烟和总能量、总脂肪、维生素C和cr-胡萝卜素摄入量的模型调整潜在混杂因素后，观察到高糖食物、总蔗糖摄入量、蔗糖与膳食纤维比率和肺癌血糖指数的风险增加(最高类别蔗糖摄入量的优势比=1.55，95%可信区间=0.99-2.44)。当按细胞类型分开分析肺癌时，小细胞和大细胞未分化癌的优势比高于肺鳞癌和腺癌。包年、总脂肪摄入量和蔗糖摄入量的共同作用与这三个变量高值的风险增加28.3(95%可信区间=13.4-59.7)相关。这项研究表明，高蔗糖摄入量可能是肺癌发生的重要危险因素。需要进一步的流行病学和实验研究，以重复目前的发现，并澄清蔗糖摄入在肺癌发生中的机制(S)。
To examine whether dietary sugar modifies lung cancer risk, a case-control study involving 463 cases with lung cancer and 465 hospitalized controls was conducted in Uruguay in the period 1993-1996. Dietary patterns were assessed in detail using a 64-item food-frequency questionnaire, which allowed the calculation of total energy intake. After adjustment for potential confounders through a model that included tobacco smoking and total energy, total fat, vitamin C, and cr-carotene intakes, an increased risk for sugar-rich foods, total sucrose intake, sucrose-to-dietary fiber ratio, and glycemic index for lung cancer was observed (odds ratio for highest category of total sucrose intake = 1.55, 95% confidence interval = 0.99-2.44). When lung cancer was analyzed separately by cell type, odds ratios for small cell and large cell undifferentiated carcinoma were higher than those observed for squamous cell and adenocarcinoma of the lung. The joint effect of pack-years, total fat intake, and sucrose intake was associated with an increased risk of 28.3 (95% confidence interval = 13.4-59.7)for high values of the three variables. The study suggests that high sucrose intake could be an important risk factor in lung carcinogenesis. Further studies, both epidemiological and experimental, are needed to replicate the present findings and to clarify the mechanism(s) of sucrose intake in lung carcinogenesis.