The influence of genetic variation in oxidative stress genes on human noise susceptibility
The influence of genetic variation in oxidative stress genes on human noise susceptibility
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DOI：
10.1016/j.heares.2004.09.005
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发表时间：
2005-04-01
期刊：
影响因子：
2.8
通讯作者：
Van Camp, G
中科院分区：
文献类型：
--
作者：
Carlsson, PI;Van Laer, L;Van Camp, G
噪声性听力损失（NIHL）是一种由遗传和环境因素相互作用引起的复杂疾病。噪声暴露对耳蜗的损伤似乎是由活性氧介导的。为了研究人类保护性抗氧化系统的遗传变异是否与NIHL的高或低易感性相关，我们分析了1200名瑞典噪声暴露工人中10%最敏感和10%最耐极端的氧化应激反应基因的遗传多态性。其中GSTM1和GSTT1基因缺失2个，CAT、SOD、GPX、GSR和GSTP1基因SNPs 14个。未发现易感组和耐药组之间存在显著差异，未支持抗氧化酶的遗传变异在NIHL易感性中的主要作用。(c)2004 Elsevier B.V.保留所有权利。
Noise induced hearing loss (NIHL) is a complex disease Caused by an interaction between genetic and environmental factors. Damage in the cochlea as a result of noise exposure appears to be mediated by reactive oxygen species (ROS). To investigate whether genetic variation in the human protective antioxidant system is associated with high or low susceptibility to NIHL genetic polymorphisms derived from genes involved in the oxidative stress response were analysed in the 10% most susceptible and 10% most resistant extremes of 1200 Swedish noise-exposed workers. The genetic polymorphisms included 2 deletion polymorphisms for the GSTM1 and GSTT1 gene, and 14 SNPs derived from the CAT, SOD, GPX, GSR and GSTP1 genes. No significant differences were found between susceptible and resistant groups, providing no support for a major role of genetic variation of antioxidant enzymes in the susceptibility to NIHL. (c) 2004 Elsevier B.V. All rights reserved.