Nestin is a novel marker for renal tubulointerstitial injury in immunoglobulin A nephropathy
Nestin is a novel marker for renal tubulointerstitial injury in immunoglobulin A nephropathy
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DOI：
10.1111/j.1440-1797.2010.01342.x
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发表时间：
2010-08
期刊：
影响因子：
2.5
通讯作者：
M. Tomioka;K. Hiromura;T. Sakairi;Shigeru Takeuchi;A. Maeshima;Y. Kaneko;T. Kuroiwa;T. Takeuchi;Y. Nojima
中科院分区：
文献类型：
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作者：
M. Tomioka;K. Hiromura;T. Sakairi;Shigeru Takeuchi;A. Maeshima;Y. Kaneko;T. Kuroiwa;T. Takeuchi;Y. Nojima
目的：巢蛋白是一种神经前体细胞的中间纤维，在肾脏发育过程中在内皮细胞和肾小管上皮细胞中瞬时表达。然而，在成人肾脏中，足细胞是唯一表达巢蛋白的细胞。在这项研究中，我们研究了人类肾小球肾炎肾小管间质巢蛋白的表达。
Aim: Nestin, an intermediate filament originally identified as a marker of neural progenitor cells, is transiently expressed in endothelial cells and tubuloepithelial cells during kidney development. However, in adult kidneys, podocytes are the only cells that express nestin. In this study, we examined tubulointerstitial nestin expression in human glomerulonephritis.