A DIRECT PROJECTION FROM THE CENTRAL NUCLEUS OF THE AMYGDALA TO THE ACOUSTIC STARTLE PATHWAY - ANTEROGRADE AND RETROGRADE TRACING STUDIES
A DIRECT PROJECTION FROM THE CENTRAL NUCLEUS OF THE AMYGDALA TO THE ACOUSTIC STARTLE PATHWAY - ANTEROGRADE AND RETROGRADE TRACING STUDIES
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DOI：
10.1037/0735-7044.105.6.817
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发表时间：
1991-12-01
影响因子：
1.9
通讯作者：
DAVIS, M
中科院分区：
文献类型：
--
作者：
ROSEN, JB;HITCHCOCK, JM;DAVIS, M
先前的工作表明，杏仁核中央核的病变块恐惧增强声惊吓和中央核的电刺激增强大鼠的声惊吓。 在本研究中，顺行示踪剂菜豆-白细胞凝集素被用来识别和描绘的过程中，从中央核的杏仁核的脑桥尾侧网状核，核在声学惊吓电路的直接投射。 使用逆行示踪剂Fluoro-Gold的实验证实了这一点，并表明杏仁核中央核内侧亚部的吻侧部分包含投射到惊吓回路的细胞。 有了这些信息，病变研究（见配套文章希区柯克和戴维斯，1991）可以用来确定是否这种投射在恐惧增强惊吓中发挥作用。
Previous work has shown that lesions of the central nucleus of the amygdala block fear-potentiated acoustic startle and that electrical simulation of the central nucleus enhances acoustic startle in rats. In the present study, the anterograde tracer Phaseolus vulgaris-leucoagglutinin was used to identify and delineate the course of a direct projection from the central nucleus of the amygdala to the nucleus reticularis pontis caudalis, a nucleus in the acoustic startle circuit. Experiments using the retrograde tracer Fluoro-Gold confirmed this and indicated that the rostral part of the medial subdivision of the central nucleus of the amygdala contains the cells that project to the startle circuit. With this information, lesion studies (see companion article Hitchcock & Davis, 1991) may be used to determine whether this projection plays a role in fear-potentiated startle.