Epidemiological study of fowl glioma-inducing virus in chickens in Asia and Germany
Epidemiological study of fowl glioma-inducing virus in chickens in Asia and Germany
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DOI：
10.1080/03079457.2012.684373
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发表时间：
2012-01-01
期刊：
影响因子：
2.8
通讯作者：
Umemura, Takashi
中科院分区：
文献类型：
--
作者：
Ochi, Akihiro;Ochiai, Kenji;Umemura, Takashi
禽神经胶质瘤诱导病毒（FGV）是禽白血病病毒（ALV）A亚群的一种，可诱导鸡的神经胶质瘤。这种疾病的特征是星形胶质细胞的多发性结节性胶质瘤样生长，以前在欧洲、南非、澳大利亚、美国和日本都有报道。FGV和FGV变种已经传播到日本观赏鸡，包括日本矮脚鸡（Gallus gallus arcticus）。然而，FGV是如何出现的，在哪里出现的，以及FGV是否与欧洲国家过去发生的鸡胶质瘤有关还不清楚。在这项研究中，欧洲，亚洲和日本本土鸡FGV的流行进行了检查。在德国和除日本以外的亚洲国家的任何鸡中均未分离到FGV。在日本饲养的307只鸡中，80只（26%）通过FGV筛选巢式聚合酶链反应呈阳性，并分离出11种在其3'非翻译区具有FGV特异性序列的FGV变体。此外，从患有鸡神经胶质瘤和/或小脑发育不全的日本矮脚鸡中分离出其他四种缺乏FGV特异性序列的ALV。这些分离株被认为是FGV变体和内源性/外源性禽类逆转录病毒之间的不同重组病毒。这些结果表明，变异体以及不同的重组ALV在日本的日本本土鸡中普遍存在，FGV可能是通过在该国鸡中的禽类逆转录病毒之间重组而出现的。
Fowl glioma-inducing virus (FGV), which belongs to avian leukosis virus (ALV) subgroup A, induces fowl glioma. This disease is characterized by multiple nodular gliomatous growths of astrocytes and has been previously reported in Europe, South Africa, Australia, the United States and Japan. FGV and FGV variants have spread to ornamental Japanese fowl, including Japanese bantams (Gallus gallus domesticus), in Japan. However, it is unclear how and where FGV emerged and whether FGV is related to the past fowl glioma in European countries. In this study, the prevalence of FGV in European, Asian and Japanese native chickens was examined. FGV could not be isolated from any chickens in Germany and Asian countries other than Japan. Eighty (26%) out of 307 chickens reared in Japan were positive by FGV-screening nested polymerase chain reaction and 11 FGV variants with an FGV-specific sequence in their 3' untranslated region were isolated. In addition, four other ALVs lacking the FGV-specific sequence were isolated from Japanese bantams with fowl glioma and/or cerebellar hypoplasia. These isolates were considered to be distinct recombinant viruses between FGV variants and endogenous/exogenous avian retroviruses. These results suggest that the variants as well as distinct recombinant ALVs are prevalent among Japanese native chickens in Japan and that FGV may have emerged by recombination among avian retroviruses in the chickens of this country.