Aluminum, Alzheimer's disease, and the olfactory system.
Aluminum, Alzheimer's disease, and the olfactory system.
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铝、阿尔茨海默病和嗅觉系统。
DOI：
10.1111/j.1749-6632.1991.tb00183.x
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发表时间：
1991
影响因子：
5.2
通讯作者：
Good,PF
中科院分区：
文献类型：
--
作者：
Perl,DP;Good,PF
在阿尔茨海默氏病中，已经认识到在与嗅觉系统相关的皮质区域的神经元之间存在神经元缠结的戏剧性发展趋势。我们已经证明，神经元缠结轴承神经元含有显着升高水平的铝。嗅觉系统是中枢神经系统中唯一暴露于外部环境的部分，具有独特的吸收和跨神经元传播外源性物质的能力。我们认为，由于铝是不采用任何生理过程中，这些存款必须从外源性来源。使用帕金森病痴呆症复杂的关岛作为一个模型，我们目前的数据表明，嗅觉系统是特别容易受到损害，并在疾病的早期受到影响。这支持了这样的概念，即病原体的重要性，这种流行病可能是空气传播的性质，并可能通过嗅觉途径进入中枢神经系统。
In Alzheimer's disease, it has been recognized that there is a dramatic tendency for the development of neurofibrillary tangles among neurons of cortical regions associated with the olfactory system. We have demonstrated that neurofibrillary tangle-bearing neurons contain dramatically elevated levels of aluminum. The olfactory system, the only portion of the central nervous system with exposure to the external environment, is uniquely capable of uptake and transneuronal spread of exogenous substances. We argue that inasmuch as aluminum is not employed in any physiologic process, these deposits must arise from exogenous sources. Using parkinsonism-dementia complex of Guam as a model, we present data which suggest that the olfactory system is particularly vulnerable to damage and is affected very early in the disease. This supports the concept that etiologic agents of importance to this epidemic may be airborne in nature and may enter the central nervous system via the olfactory pathways.