Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production
Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production
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DOI：
10.1016/j.prp.2007.10.008
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Barral-Netto, Manoel
中科院分区：
文献类型：
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作者：
de Noronha, Almerio L. L.;Bafica, Andre;Barral-Netto, Manoel
结核病/HIV-1合并感染每年造成数千人死亡，以前的研究报告称，合并感染的个体在组织肉芽肿中显示出重大的形态学改变。本研究的目的是评估肺结核/HIV-1合并感染者肺组织的免疫组织病理学特征。尸检后，结核病阳性HIV-1阴性病例显示肉芽肿，结构正常，主要由典型上皮样单核细胞浸润和巨细胞组成，并显示干酪样坏死。相反，TB/HIV-1共感染组的病变表现为广泛坏死、形成不良的肉芽肿和明显存在的多形核细胞。更重要的是，TNF染色在TB/HIV-1共感染个体中大大减少。我们的数据表明，HIV-1感染通过调节TNF和可能的细胞运输改变了肺肉芽肿的组织结构，导致抗结核反应受损。(C)2007年，Elsevier GmbH。All rights reserved.
Tuberculosis/HIV-1 co-infection is responsible for thousands of deaths each year, and previous studies have reported that co-infected individuals display major morphological alterations in tissue granulomas. The purpose of this study was to evaluate immunohistopathological characteristics in lung tissues from pulmonary TB/HIV-1-co-infected individuals. Following autopsy, tuberculosis-positive HIV-1-negative cases displayed granulomas with normal architecture, mainly composed of a mononuclear infiltrate with typical epithelioid, as well as giant cells, and exhibiting caseous necrosis. In contrast, lesions from the TB/HIV-1-co-infected group showed extensive necrosis, poorly formed granulomas, and a marked presence of polymorphonuclear cells. More importantly, TNF staining was greatly reduced in the TB/HIV-1-co-infected individuals. Our data suggest that HIV-1 infection alters the organization of pulmonary granulomas by modulating TNF and, possibly, cell trafficking, leading to an impaired anti-tuberculosis response. (C) 2007 Elsevier GmbH. All rights reserved.