Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma.
Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma.
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DOI：
10.1038/bjc.2012.35
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发表时间：
2012-02-28
影响因子：
8.8
通讯作者：
Doki, Y.
中科院分区：
文献类型：
--
作者：
Miyagaki, H.;Yamasaki, M.;Miyata, H.;Takahashi, T.;Kurokawa, Y.;Nakajima, K.;Takiguchi, S.;Fujiwara, Y.;Ishii, H.;Tanaka, F.;Mori, M.;Doki, Y.
关键词：
最近，PFTK 1被确定为细胞周期蛋白依赖性激酶家族的成员，然而，其在食管鳞状细胞癌（ESCC）的表达和临床意义尚未进行评估。应用基因表达谱芯片检测77例食管鳞癌患者PFTK 1的表达。使用223例患者的独立样本，PFTK 1表达进行了化学评价，以评估表达和各种临床病理参数之间的关系。PFTK 1和化疗反应之间的关联也在85例接受化疗作为首次治疗的患者的预处理样本中进行了研究。与正常上皮相比，食管鳞癌中PFTK 1的表达显著上调。PFTK 1表达阳性率为51.6%（115/223），但与任何临床病理参数无关。PFTK 1阳性表达者5年生存率（43.6%）明显低于阴性表达者（66.2%）（P<0.001）。单因素和多因素分析显示PFTK 1是独立的预后指标（RR=2.428，95% CI=1.615-3.711，P<0.001）。在85份活检样本中，40份（47.1%）肿瘤显示PFTK 1阳性表达，对化疗的有效率明显低于PFTK 1阴性肿瘤（27.9% vs 72.1%，P<0.001）。PFTK 1不仅可作为预后标志物，而且可作为化疗反应的预测因子。
Recently, PFTK1 was identified as a member of the cyclin-dependent kinase family; however, its expression and clinical significance in oesophageal squamous cell carcinoma (ESCC) have not been evaluated. PFTK1 expression was initially examined by expression microarray in 77 ESCC patients. Using independent samples of 223 patients, PFTK1 expression was evaluated immunohistochemically to assess the relationship between expression and various clinicopathological parameters. The association between PFTK1 and the response to chemotherapy was also investigated in pretreatment samples of 85 patients who received chemotherapy as first treatment. Significant upregulation of PFTK1 expression was noted in ESCC compared with normal epithelium. PFTK1 expression was positive in 51.6% (115 out of 223) of the tumours, but did not correlate with any clinicopathological parameter. The 5-year overall survival rate was poorer in patients positive for PFTK1 (43.6%) than those with negative expression (66.2%, P<0.001). Uni- and multivariate analyses identified PFTK1 as an independent marker of prognosis (RR=2.428, 95% CI=1.615–3.711, P<0.001). Out of 85 biopsy samples, 40 (47.1%) tumours showed PFTK1-positive expression, and the response rate to chemotherapy was significantly lower than PFTK1-negative tumours (27.9% vs 72.1%, P<0.001). PFTK1 is not only useful as a prognostic marker, but also as a predictor of the response to chemotherapy.
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影响因子：
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作者：
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通讯作者：
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作者：
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作者：
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DOI：
10.1186/bcr2231
发表时间：
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期刊：
Breast cancer research : BCR
影响因子：
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作者：
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通讯作者：
Ueno NT