Ubiquitins revisited: further examples of within- and between-locus concerted evolution.
Ubiquitins revisited: further examples of within- and between-locus concerted evolution.
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DOI：
10.1006/mpev.1993.1035
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发表时间：
1993-12
影响因子：
4.1
通讯作者：
Y. Tan;S. Bishoff;M. Riley
中科院分区：
文献类型：
--
作者：
Y. Tan;S. Bishoff;M. Riley
泛素基因为研究协同进化对短重复序列家族进化的影响提供了一个模型。以前的工作已经证明了基因座内协同进化的发生，并提出了基因座间协同进化对泛素重复序列的有效性的问题。在这项研究中，对泛素串联重复序列的其他核苷酸序列的比较分析提供了位点内协同进化的进一步细节。此外，一个物种内多个多泛素位点和泛素融合位点的可用性使得检测位点间协同进化成为可能。这些数据表明，协同进化是基因座之间以及基因座内部重复均质化的有效力量。
Ubiquitin genes provide a model for studying the effects of concerted evolution on the evolution of a family of short repeated sequences. Previous work has demonstrated the occurrence of within-locus concerted evolution and raised the question of the effectiveness of between-locus concerted evolution for ubiquitin repeats. In this study comparative analysis of additional nucleotide sequences of ubiquitin tandem repeats provides further details of within-locus concerted evolution. Moreover, the availability of multiple polyubiquitin loci and ubiquitin fusion loci within a species makes possible the detection of between-locus concerted evolution. These data indicate that concerted evolution is an effective force for homogenizing repeats between, as well as within, loci.