Conjunctival lymphocytic nodule associated with the Epstein-Barr virus.
Conjunctival lymphocytic nodule associated with the Epstein-Barr virus.
复制标题
与 Epstein-Barr 病毒相关的结膜淋巴细胞结节。
DOI：
10.1016/s0002-9394(14)76860-6
复制
发表时间：
1991
影响因子：
4.2
通讯作者：
Mondino,BJ
中科院分区：
文献类型：
--
作者：
Gardner,BP;Margolis,TP;Mondino,BJ
据报道，爱泼斯坦-巴尔病毒感染具有许多全身和眼部表现。在这项研究中，一个38岁的男子与急性传染性单核细胞增多症检查无痛左眼红眼的三天的时间。患者有两周的疲乏、低热、咽喉痛和淋巴结病史。血清学评价提示急性原发性EB病毒感染。在左眼中观察到一个大的鲑鱼色鼻上球结膜肿块。未出现相关结膜炎。结膜病变的活检显示致密的白细胞浸润，主要由成熟淋巴细胞和浆细胞组成。用单克隆抗血清对组织进行免疫细胞化学评价，发现在构成浸润的一小部分细胞中存在EB潜伏膜蛋白和核蛋白2。结膜浸润在一个月内完全消退，与患者淋巴结病的消退平行。
Infection with Epstein-Barr virus has been reported to have numerous systemic and ocular manifestations. In this study, a 38-year-old man with acute infectious mononucleosis was examined for a painless left red eye of three day's duration. The patient had a two-week history of fatigue, low-grade fever, sore throat, and lymphadenopathy. Serologic evaluation was indicative of an acute primary infection with Epstein-Barr virus. A large, salmon-colored, supranasal bulbar conjunctival mass was observed in the left eye. No associated conjunctivitis was present. Biopsy of the conjunctival lesion disclosed a dense leukocytic infiltrate, which consisted primarily of mature lymphocytes and plasma cells. Immunocytochemical evaluation of the tissue with monoclonal antisera disclosed EpsteinBarr latent membrane protein and nuclear protein 2 in a small fraction of the cells constituting the infiltrate. The conjunctival infiltrate resolved completely within one month, paralleling the regression of the patient's lymphadenopathy.