The effect of aging on the cutaneous microvasculature
The effect of aging on the cutaneous microvasculature
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DOI：
10.1016/j.mvr.2015.04.004
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发表时间：
2015-07-01
影响因子：
3.1
通讯作者：
Reed, May J.
中科院分区：
文献类型：
--
作者：
Bentov, Itay;Reed, May J.
衰老与所有器官的功能逐渐丧失有关。在正常情况下，对年龄相关缺陷的生理补偿是足够的，但在应激期间，这种储备的局限性变得明显。对这种储备减少的解释包括在正常衰老过程中发生的微循环的变化。微循环被定义为通过小动脉、毛细血管和小静脉的血液流动，小动脉、毛细血管和小静脉是脉管系统中最小的血管并且嵌入器官和组织内。在手术和其他应激源后维持微血管的最佳策略必须使用多因素方法。使用皮肤作为模型器官，我们将回顾微循环随年龄增长的解剖学和功能变化，以及一些可用的临床策略，以潜在地减轻这些变化对重要临床结果的影响。(C)2015 Elsevier Inc. All rights reserved.
Aging is associated with a progressive loss of function in all organs. Under normal conditions the physiologic compensation for age-related deficits is sufficient, but during times of stress the limitations of this reserve become evident. Explanations for this reduction in reserve include the changes in the microcirculation that occur during the normal aging process. The microcirculation is defined as the blood flow through arterioles, capillaries and venules, which are the smallest vessels in the vasculature and are embedded within organs and tissues. Optimal strategies to maintain the microvasculature following surgery and other stressors must use multifactorial approaches. Using skin as the model organ, we will review the anatomical and functional changes in the microcirculation with aging, and some of the available clinical strategies to potentially mitigate the effect of these changes on important clinical outcomes. (C) 2015 Elsevier Inc. All rights reserved.