JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp NBRC 105896 isolated from a marine sponge
JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp NBRC 105896 isolated from a marine sponge
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DOI：
10.1038/ja.2009.113
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发表时间：
2010-01-01
影响因子：
3.3
通讯作者：
Shin-ya, Kazuo
中科院分区：
文献类型：
--
作者：
Izumikawa, Miho;Khan, Shams Tabrez;Shin-ya, Kazuo
海洋环境最近被描述为药物发现的新型化学多样性的来源，1因为许多生物活性物质是从海洋生物中分离出来的，包括浮游植物、藻类、海绵、被囊动物和软体动物。2，3我们小组还报道了从海绵中分离到azaspiracid-2 4和JBIR-44 5。来自海洋生境的微生物，6、7特别是放线菌，也是一种有前途的尚未开发的新化合物资源，正受到特别关注。与高等生物相比，微生物可以在实验室条件下容易地维持，确保其次级代谢产物的恒定和廉价的供应。此外，最初被认为是由海洋生物产生的化合物后来被发现是由宿主相关的微生物产生的。8.在过去10年中，在从海洋生境中分离放线菌方面开展了大量工作，对放线菌的筛选产生了几种新的生物活性化合物。9-11我们的团队最近从事海洋微生物的分离，包括真菌和放线菌。发现一些分离的真菌产生新的化合物，即JBIR-27，-28，12-15，13-37和-38。14在放线菌中，链霉菌属的许多新成员是从海绵Haliclona sp.中分离出来的。15有趣的是，许多分离的菌株需要盐才能最佳生长。这些菌株对盐的需求可能表明它们的海洋起源。从盐生菌中分离得到一株需要盐的链霉菌NBRC 105896。当测试其产生新的次级代谢产物时，链霉菌NBRC 105896产生一种新的精杀藻素类似物，命名为JBIR-31（1），具有8种已知化合物。本文
The marine environment has recently been described as a source of novel chemical diversity for drug discovery, 1 as many bioactive substances are isolated from marine organisms including phytoplankton, algae, sponges, tunicates and mollusks. 2, 3 Our group has also reported the isolation of azaspiracid-2 4 and JBIR-44 5 from marine sponges. Microorganisms from marine habitats, 6, 7 especially actinobacteria, also constitute a promising untapped resource of novel compounds and are receiving special attention. Compared with higher organisms, microorganisms can be easily maintained under laboratory conditions ensuring a constant and inexpensive supply of their secondary metabolites. Moreover, compounds originally thought to be produced by a marine organism were later found to be produced by hostassociated microorganisms. 8 A significant body of work has emerged in the past 10 years on the isolation of actinobacteria from marine habitats and their screening has yielded several novel bioactive compounds. 9–11Our group recently engaged in the isolation of microorganisms from marine sources including fungi and actinobacteria. Some of the isolated fungi were found to produce novel compounds, namely, JBIR-27,-28, 12-15, 13-37 and-38. 14 Among actinobacteria, many novel members of the genus Streptomyces were isolated from a marine sponge Haliclona sp. 15 Interestingly, many of the isolated strains required salt for their optimal growth. The requirement of salt by these strains may indicate their marine origin. One such salt-requiring strain Streptomyces sp. NBRC 105896 was isolated from Haliclona sp. When tested for the production of novel secondary metabolites, Streptomyces sp. NBRC 105896 produced a novel teleocidin analog designated as JBIR-31 (1) with eight known compounds. This paper