The Role of Social Relationships in PrEP Uptake and Use Among Transgender Women and Men Who Have Sex with Men.

The Role of Social Relationships in PrEP Uptake and Use Among Transgender Women and Men Who Have Sex with Men.
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社会关系在与男性发生性关系的跨性别男女中的预期吸收和使用中的作用。

DOI:
10.1007/s10461-018-2151-0
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发表时间:
2018-11
期刊:
影响因子:
4.4
通讯作者:
Grant RM
Grant RM
中科院分区:
医学2区
文献类型:
--
作者:
Mehrotra ML;Rivet Amico K;McMahan V;Glidden DV;Defechereux P;Guanira JV;Grant RM

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定性研究表明,社会关系在艾滋病毒暴露前预防(PrEP)的使用中发挥重要作用,但很少有定量评估社会关系在PrEP摄取或依从性中的作用。我们在iPrEx OLE研究中招募了1603名hiv阴性参与者,研究了参与研究或LGBT身份与PrEP使用之间的关系。我们还评估了LGBT社会群体参与与PrEP使用之间的关系。向父母透露参与研究的情况,以及向参与者社交网络中的任何人透露LGBT身份,与更多的PrEP接受有关。向伴侣透露参与研究的情况与服用保护性PrEP药物浓度的可能性较高相关(风险差0.15 95%CI[0.01, 0.30])。每增加一种LGBT组织类型,参与者服用PrEP和服用保护性药物浓度的概率分别增加0.04 (95%CI[0.03, 0.06])和0.04 (95%CI[0.02, 0.07])。总体而言,社会环境与iPrEx OLE中PrEP的使用有关,在设计未来的PrEP实施方案时应考虑到这一点。
Qualitative studies suggest that social relationships play an important role in HIV pre-exposure prophylaxis (PrEP) use, but there have been few quantitative assessments of the role of social relationships in PrEP uptake or adherence. We examined the association between disclosure of study participation or LGBT identity and PrEP use in the 1603 HIV-negative participants enrolled in the iPrEx OLE study. We also evaluated the association between LGBT social group involvement and PrEP use. Study participation disclosure to parents and LGBT identity disclosure to anyone in a participant’s social network were associated with greater PrEP uptake. Study participation disclosure to partners was associated with higher probability of having protective PrEP drug concentrations compared (risk difference 0.15 95%CI [0.01, 0.30]). For each additional type of LGBT organization a participant was involved in, the probability of PrEP uptake and having protective drug concentrations increased by 0.04 (95%CI [0.03, 0.06]) and 0.04 (95%CI [0.02, 0.07]) respectively. Overall, social context was associated with PrEP use in iPrEx OLE, and should be taken into consideration when designing future PrEP implementation programs.
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