Partial liquid ventilation protects lung during resuscitation from shock.
Partial liquid ventilation protects lung during resuscitation from shock.
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部分液体通气可在复苏过程中保护肺部免受休克。
DOI：
10.1152/jappl.1997.83.5.1666
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Hirschl,RB
中科院分区：
文献类型：
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作者：
Younger,JG;Taqi,AS;Till,GO;Hirschl,RB
Younger、John G.、Ali S. Taqi、Gerd O. Till 和 Ronald B. Hirschl。部分液体通气可在休克复苏过程中保护肺部。应用。 Physiol.83(5): 1666–1670, 1997.—部分液体通气 (PLV) 的初步动物经验表明，这种疗法可能会减少急性肺损伤期间的中性粒细胞侵袭和毛细血管渗漏。我们试图在休克引起的肺损伤模型中证实这些发现。对六十只麻醉大鼠进行了研究。出血至动脉压25mmHg持续45分钟后，用血液和盐水对动物进行复苏，并单独进行气体通气或用5ml/kg气管内施用perflubron进行治疗。髓过氧化物酶活性用于测量肺中性粒细胞含量。渗透性指数（125 I标记的白蛋白活性的支气管肺泡与血液的比率）量化了肺泡渗漏。损伤导致髓过氧化物酶增加，PLV 可逆转这一现象（损伤 = 0.837 ± 0.452，PLV = 0.257 ± 0.165；P < 0.01）。毛细血管通透性也随着出血而增加，PLV 组有明显改善的趋势（渗透性指数：损伤 = 0.094 ± 0.102，PLV = 0.045 ± 0.045；损伤的 95% 置信区间 - PLV：-0.024，0.1219）。我们得出的结论是，PLV 与失血性休克后肺中性粒细胞积累的减少和毛细血管渗漏减少的趋势有关。
Younger, John G., Ali S. Taqi, Gerd O. Till, and Ronald B. Hirschl.Partial liquid ventilation protects lung during resuscitation from shock.J. Appl. Physiol.83(5): 1666–1670, 1997.—Preliminary animal experience with partial liquid ventilation (PLV) suggests that this therapy may diminish neutrophil invasion and capillary leak during acute lung injury. We sought to confirm these findings in a model of shock-induced lung injury. Sixty anesthetized rats were studied. After hemorrhage to an arterial pressure of 25 mmHg for 45 min, animals were resuscitated with blood and saline and treated with gas ventilation alone or with 5 ml/kg of intratracheally administered perflubron. Myeloperoxidase activity was used to measure lung neutrophil content. A permeability index (the bronchoalveolar-to-blood ratio of125I-labeled albumin activity) quantified alveolar leak. Injury caused an increase in myeloperoxidase that was reversed by PLV (injury = 0.837 ± 0.452, PLV = 0.257 ± 0.165;P< 0.01). Capillary permeability also increased with hemorrhage, with a strong trend toward improvement in the PLV group (permeability indexes: injury = 0.094 ± 0.102, PLV = 0.045 ± 0.045; 95% confidence interval for injury − PLV: −0.024, 0.1219). We conclude that PLV is associated with a decrease in pulmonary neutrophil accumulation and a trend toward decreased capillary leak after hemorrhagic shock.