Centromeric chromatin and the pathway that drives its propagation.

Centromeric chromatin and the pathway that drives its propagation.
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DOI:
10.1016/j.bbagrm.2011.11.002
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发表时间:
2012-03
影响因子:
4.7
通讯作者:
Black, Ben E.
Black, Ben E.
中科院分区:
生物学2区
文献类型:
--
作者:
Falk, Samantha J.;Black, Ben E.

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The centromere is the locus that directs chromosomal inheritance at cell division. While centromeres in diverse eukaryotes are commonly found at sites of repetitive DNA, their location is epigenetically specified. The histone H3 variant CENP-A is the prime candidate for epigenetically marking the centromere, and recent work has uncovered several additional proteins that play key roles in centromere assembly and maintenance. We describe advances in the identification and characterization of proteins that form the centromere, and focus on recent findings that have advanced our understanding of the assembly of functional centromeric chromatin.
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