DEFICITS ON A SPATIAL NAVIGATION TASK FOLLOWING PRENATAL EXPOSURE TO ETHANOL
DEFICITS ON A SPATIAL NAVIGATION TASK FOLLOWING PRENATAL EXPOSURE TO ETHANOL
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DOI：
10.1016/0892-0362(87)90010-9
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发表时间：
1987-05-01
影响因子：
2.9
通讯作者：
HANNIGAN, JH
中科院分区：
文献类型：
--
作者：
BLANCHARD, BA;RILEY, EP;HANNIGAN, JH
在莫里斯水任务中，研究人员测试了年轻大鼠的表现，这些老鼠的母亲在怀孕期间食用含有35%乙醇衍生卡路里（EDC）的液体食物。配对饲养（0% EDC）和实验室饲料（LC）的后代作为对照。老鼠被要求在一池不透明的水中找到一个淹没在水面下的平台。当大鼠在平台上停留15秒或在水箱中停留180秒而未到达平台时，试验结束。受试者每天接受5次试验，连续3天，第4天进行逆转训练。各组在游泳能力上没有差异。在第1天，雌性动物到达平台的潜伏期和行进距离没有组间差异，但35% EDC和0% EDC的雄性动物的潜伏期比LC对照组短。在第2天，LC和0% EDC对照组的潜伏期和移动距离减少，而35% EDC的动物与第1天相比没有变化，因此酒精暴露大鼠到达平台所需的时间更长，移动的距离也更长。在第3天，3%的雌性EDC动物比对照组花了更长的时间到达平台，35%的雌性EDC动物比对照组走了更长的距离。第4天的第一次逆转试验的搜索模式表明，差异在于空间处理，而不是学习本身，但酒精暴露的男性比女性更明显。在这项任务中受损的表现表明，产前酒精暴露改变了处理空间信息的能力。
Performance on a Morris water task was examined in young rats whose mothers consumed a liquid diet consisting of 35% ethanol-derived calories (EDC) during pregnancy. Offspring of pair-fed (0% EDC) and ad lib lab chow (LC) dams served as controls. Rats were required to find a platform submerged below the surface in a pool of opaque water. A trial ended when the rat remained on the platform for 15 sec, or had been in the tank for 180 sec without reaching the platform. Subjects received 5 trials daily for 3 consecutive days, followed by reversal training on Day 4. Groups did not differ in swimming ability. On Day 1 there were no group differences among females in latency to reach the platform or in distance traveled, but male 35% EDC and 0% EDC animals had shorter latencies than LC controls. On Day 2, latencies and distance traveled of LC and 0% EDC controls decreased while 35% EDC animals showed no change from Day 1, so that alcohol-exposed rats took longer to reach the platform and traveled a greater distance than controls. On Day 3, 3% EDC females took longer than controls to reach the platform, and 35% EDC animals of both sexes traveled a greater distance than controls. Search patterns on the first reversal trial on Day 4 suggest the differences are in spatial processing and not learning per se, but more so in alcohol-exposed males than females. The impaired performance on this task suggest that prenatal alcohol exposure alters the ability to process spatial information.